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Nocturnal Hypertension Ups cIMT in Youth With Diabetes

Increased carotid intima-media thickness in children with nocturnal hypertension, diabetes

THURSDAY, Sept. 22 (HealthDay News) -- Nocturnal hypertension in children and adolescents with type 1 diabetes is associated with increased carotid intima-media thickness (cIMT), according to a study published online Sept. 12 in Diabetes Care.

Sun Hee Lee, M.D., from Inje University in Korea, and colleagues investigated the effects of nocturnal hypertension on atherosclerosis in children and adolescents with type 1 diabetes, and the association between atherogenic risk factors and cIMT. A total of 82 children and adolescents with type 1 diabetes underwent ambulatory blood pressure monitoring (ABPM) and were examined for cIMT. Hemoglobin A1c levels, 24-hour urine microalbumin excretion, lipid profiles, and duration of diabetes were assessed. Hypertension observed only at night was classified as nocturnal hypertension.

The investigators found that 43 participants (52 percent) had hypertension, 30 of whom had nocturnal hypertension. The nocturnal hypertension group had higher cIMT (0.44 ± 0.03 mm) compared to that in the normotensive group (0.42 ± 0.04 mm). In the group with nonhypertensive blood pressure levels in clinic blood pressure monitoring, those with nocturnal hypertension had higher levels of cIMT and daytime blood pressure. Multiple linear regression analysis revealed a significant association of all ABPM parameters with cIMT.

"This is the first study to show a relationship between nighttime blood pressure and cIMT and that nighttime blood pressure may indirectly predict the degree of atherosclerosis in children with type 1 diabetes," the authors write.

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