Depressive Symptoms Tied to Incident T2DM in Black Women

Depressive symptoms and antidepressant use linked to increased incidence rate ratios

Depressive Symptoms Tied to Incident T2DM in Black Women

MONDAY, June 16, 2014 (HealthDay News) -- Among African-American women, depressive symptoms and antidepressant use are associated with incident type 2 diabetes, according to a study published online June 5 in Diabetes Care.

Varsha G. Vimalananda, M.D., M.P.H., from the Boston University School of Medicine, and colleagues examined the correlation between depressive symptoms and antidepressant use with incident type 2 diabetes using data from 35,898 women from the Black Women's Health Study. Participants completed the Center for Epidemiologic Studies Depression Scale (CES-D) in 1999 and were followed through 2011.

The researchers identified 3,372 incident diabetes cases over 12 years of follow-up. Compared with a CES-D score of <16, the incidence rate ratios of diabetes were 1.23 (95 percent confidence interval [CI], 1.12 to 1.35), 1.26 (95 percent CI, 1.12 to 1.41), and 1.45 (95 percent CI, 1.24 to 1.69) for CES-D scores of 16 to 22, 23 to 32, and ≥33, in a basic multivariate model that included age, time period, family history of diabetes, and education. The incidence rate ratios were attenuated to 1.11 (95 percent CI, 1.01 to 1.22), 1.08 (95 percent CI, 0.96 to 1.22), and 1.22 (95 percent CI, 1.04 to 1.43), after multiple adjustment for lifestyle factors and body mass index (BMI). For antidepressant use, the adjusted incidence rate ratio was 1.26 (95 percent CI, 1.11 to 1.43). Similar results were obtained for obese women.

"Both depressive symptoms and antidepressant use are associated with incident diabetes among African-American women," the authors write. "These associations are mediated in part, but not entirely, through lifestyle factors and BMI."

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