Diabetes Family History May Not Worsen Effects of Inactivity

Findings of adipose fat metabolism at rest, to some extent, contradict prior hypothesis

TUESDAY, Nov. 30 (HealthDay News) -- First-degree relatives (FDRs) of individuals with type 2 diabetes do not appear to sustain greater deleterious effects of physical inactivity in regards to adipose tissue metabolism compared to control subjects, according to a study published in the November issue of Diabetes.

Lise Højbjerre, of the University of Copenhagen in Denmark, and colleagues investigated the effects of inactivity on 13 FDRs of individuals who have type 2 diabetes and 20 control (CON) subjects. Researchers measured the rate of each participant's glucose uptake into abdominal (SCAAT) and femoral (SCFAT) adipose tissue during normal activity. They then conducted the same measurements after 10 days of bed rest.

The researchers found significantly increased glucose uptake and significantly decreased mRNA expression of lipases in SCAAT in the FDR group. Following bed rest, lipolysis decreased and glucose uptake tended to increase in SCFAT in both the FDR and CON groups, while SCAAT glucose uptake significantly increased only in the CON group.

This finding "does to some extent reject our a priori hypothesis that FDR subjects are more sensitive to the unhealthy effects of physical inactivity than CON subjects," the authors write.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing