ENDO: HbA1c Tied to Cognition in T2DM Patients After Lacunar Stroke

Increase in HbA1c over time linked to decrease in Cognitive Assessment Screening Instrument score

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MONDAY, March 30, 2020 (HealthDay News) -- Among individuals with diabetes, hemoglobin A1c (HbA1c) is associated with cognitive scores after a lacunar stroke, according to a study presented at the virtual meeting of The Endocrine Society, held from March 28 to 31.

Tali Cukierman-Yaffe, M.D., from Tel Aviv University in Israel, and colleagues examined the effect of baseline and follow-up HbA1c on the baseline and change in Cognitive Assessment Screening Instrument (CASI) scores over time among participants with a median of two cognitive assessments. Data were examined for 942 individuals with diabetes and a lacunar stroke.

The researchers found an association for each 1 percent higher baseline HbA1c with a 0.06 lower standardized CASI z-score. Higher baseline HbA1c values were associated with a reduced CASI z-score over time. A 1 percent increase in HbA1c over time was associated with a 0.021 decrease in CASI score during follow-up. After adjustment for confounding variables, including age, sex, education, race, depression, hypertension, hyperlipidemia, body mass index, cardiovascular disease, and obstructive sleep apnea, these associations remained statistically significant.

"Identifying modifiable risk factors that are associated with cognitive dysfunction in people with type 2 diabetes who experience a lacunar stroke has major public health implications," Cukierman-Yaffe said in a statement.

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