Higher Fat Mass May Up Risk for Major Adverse CV Events in T2DM
However, increasing lean body mass does not appear to have a protective effect
MONDAY, Sept. 23, 2019 (HealthDay News) -- In patients with type 2 diabetes, higher fat mass is associated with a higher risk for major adverse cardiovascular events, according to a study published in the Sept. 23 issue of CMAJ, the journal of the Canadian Medical Association.
Zhenhua Xing, M.D., from Central South University in Changsha, China, and colleagues used data from the Action to Control Cardiovascular Risk in Diabetes study to investigate the relationship between predicted lean body mass or fat mass and major adverse cardiovascular events in patients with type 2 diabetes.
The researchers found that during a mean follow-up of 8.8 years, major cardiovascular events occurred in 1,801 of 10,251 patients (17.8 percent). There was no association between predicted lean body mass index (BMI) and major cardiovascular events. Compared with patients in the first quartile of the predicted fat mass index, those in the fourth quartile had a higher risk (hazard ratio 1.53; incidence rates, 16.4, 17.2, 17.5, and 19.8 percent for the first through fourth quartiles, respectively).
"The increased risk of CVD in [type 2 diabetes mellitus] patients with lower BMI may be attributed to the adverse effect of lower lean body mass that overrides the positive effect of lower fat mass," a coauthor said in a statement.