Remission of T2DM Without Bariatric Sx Found to Be Rare

Correlates of remission include older age, recent diagnosis, African-American race

Remission of T2DM Without Bariatric Sx Found to Be Rare

THURSDAY, Oct. 2, 2014 (HealthDay News) -- For adults with type 2 diabetes, remission is possible without bariatric surgery, but rarely occurs, according to a study published online Sept. 17 in Diabetes Care.

Andrew J. Karter, Ph.D., from Kaiser Permanente Northern California in Oakland, and colleagues examined the incidence and correlates of diabetes remission in a cohort of 122,781 adults with type 2 diabetes not treated with bariatric surgery. Remission required the absence of ongoing drug treatment and was defined as partial (at least one year of subdiabetic hyperglycemia); complete (at least one year of normoglycemia); and prolonged (complete remission for at least five years).

The researchers found that the incidence density of partial, complete, or prolonged remission was 2.8, 0.24, and 0.04 remissions per 1,000 person-years, respectively. The seven-year cumulative incidence of partial remission was 1.47 percent, complete remission was 0.14 percent, and prolonged remission was 0.007 percent. In the whole cohort and the subgroup with new onset diabetes (less than two years since diagnosis), the seven-year cumulative incidence of achieving any remission was 1.60 and 4.6 percent, respectively. Correlates of remission included age >65 years, African-American race, less than two years since diagnosis, baseline hemoglobin A1c level <5.7 percent, and no diabetes medications at baseline, after adjustment for demographic and clinical characteristics.

"In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare," the authors write.

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