Type 2 Diabetes Linked to Higher Risk for Vertebral Fractures
Patients with both T2DM, previous vertebral fracture have twofold risk for incident nonvertebral fracture
MONDAY, Nov. 4, 2019 (HealthDay News) -- Individuals with type 2 diabetes (T2D) are at higher risk for sustaining an incident vertebral fracture (VF) compared with individuals without T2D, according to a review published online Oct. 28 in Diabetes Care.
Fjorda Koromani, from the Erasmus University Medical Center in Rotterdam, Netherlands, and colleagues conducted a systematic literature review to evaluate the relationship between T2D and VFs.
Based on 15 included studies (852,705 men and women), the researchers found that individuals with T2D had a lower risk for prevalent VFs (odds ratio, 0.84; 95 percent confidence interval [CI], 0.74 to 0.95), but an increased risk for incident VFs (odds ratio, 1.35; 95 percent CI, 1.27 to 1.44). Using individual data for 19,820 participants, the risk for nonvertebral fractures was higher in those with both T2D and VFs versus those without T2D or VFs (hazard ratio [HR], 2.42; 95 percent CI, 1.86 to 3.15]) or with either VFs (HR, 1.73; 95 percent CI, 1.32 to 2.27) or T2D (HR, 1.94; 95 percent CI, 1.46 to 2.59) alone. Additionally, increased mortality was seen with individuals with both T2D and VFs versus individuals without T2D and VFs (HR, 2.11; 95 percent CI, 1.72 to 2.59) or with VFs alone (HR, 1.84; 95 percent CI, 1.49 to 2.28) or, to a lesser extent, T2D alone (HR, 1.23; 95 percent CI, 0.99 to 1.52).
"Based on our findings, individuals with T2D should be systematically assessed for presence of VFs, and, as in individuals without T2D, their presence constitutes an indication to start osteoporosis treatment for the prevention of future fractures," the authors write.