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Microalbuminuria Associated with Insulin Resistance

Declines in glucose disposal rate correlated with microalbuminuria risk in type 2 diabetics

THURSDAY, May 11 (HealthDay News) -- In patients with type 2 diabetes, declines in the glucose disposal rate increase the risk of developing microalbuminuria, according to a study in the May issue of Diabetes.

Giuseppe Remuzzi, M.D., from the Mario Negri Institute for Pharmacological Research in Bergamo, Italy, and colleagues examined the glucose disposal rate in 50 matched pairs of patients with type 2 diabetes and micro- or normoalbuminuria, as well as in 29 matched pairs of diabetic patients with macro- or microalbuminuria.

The glucose disposal rate was about 25 percent lower in patients with microalbuminuria compared with normoalbuminuria. Each 1 mg/kg/min decrease in the glucose disposal rate predicted an approximately 40 percent increase in the risk of microalbuminuria, according to the authors. Patients with a mean glucose disposal rate of 7.50 mg/kg/min or less had a threefold higher rate of microalbuminuria (60 percent versus 20 percent), and the glucose disposal rate was correlated with the urinary albumin excretion rate. In the comparison between patients with macro- and microalbuminuria, the glucose disposal rates were similar and did not correlate with the urinary albumin excretion rate, the researchers found.

"In type 2 diabetes, more severe insulin resistance is independently associated with microalbuminuria," Remuzzi and colleagues conclude.

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