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Hormones, Amino Acids Altered by Gastric Bypass Surgery

Model allowed simulation of preoperative condition and postoperative situation in the same patient

Hormones, Amino Acids Altered by Gastric Bypass Surgery

FRIDAY, May 10 (HealthDay News) -- Gastric bypass surgery alters the hormones and amino acids produced during digestion, possibly elucidating the mechanisms through which the surgery eliminates symptoms of type 2 diabetes, according to a study published in the May issue of the Journal of Clinical Endocrinology and Metabolism.

Andreas Lindqvist, Ph.D., from Lund University in Malmö, Sweden, and colleagues first gave four patients a mixed meal test (MMT) orally, preceded by overnight fast, and then gave it to them via the gastrostomy tube, preceded by two-hour fasting. Hormones and metabolites were assessed from blood samples.

The researchers found that the oral MMT produced a 4.6-fold increase in plasma insulin, a 9.3-fold increase in glucagon-like peptide-1, and a 2.5-fold increase in glucose-dependent insulinotropic peptide plasma levels (P < 0.05 for all), compared to the gastrostomy MMT. Elevated branched-chain amino acid levels (1.4 to 2-fold; P < 0.05) and suppressed fatty acid levels (approximately 50 percent; P < 0.05) accompanied the changes in hormone levels.

"These data, comparing identical nutrient delivery, demonstrate markedly higher incretin and insulin responses after oral MMT than after gastric MMT, thereby providing a potential explanation for the rapid remission of type 2 diabetes observed after gastric bypass surgery," the authors write.

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