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Reduction in Body Mass May Improve Hypothalamic Activity

Body-mass reduction may modify immunological status and functional activity of the brain

THURSDAY, June 9 (HealthDay News) -- Massive reduction in the body mass of obese individuals may improve hypothalamic dysfunctional activity, as detected by functional magnetic resonance imaging (fMRI), and may increase anti-inflammatory activity in the cerebrospinal fluid (CSF), according to a study published in the June issue of Diabetes.

Simone van de Sande-Lee, from the University of Campinas in Brazil, and colleagues investigated the effects of body-mass reduction on brain functionality in 13 obese and eight lean individuals between the ages of 18 and 60 years. Changes in brain activity before and after massive weight reduction following bariatric surgery were assessed by two analytic methods of fMRI. CSF was collected at the time of surgery and after reduction of body mass.

The investigators found that, compared to lean individuals, certain brain regions of obese patients had distinct functional activity patterns. Following bariatric surgery and loss of body mass, the CSF concentration of interleukin-10 and interleukin-6 increased, and changes in fMRI patterns were seen, especially in the hypothalamus.

"Reduction of body mass in obese humans increases the anti-inflammatory activity in the CSF and partially corrects the dysfunctional activity in response to glucose in selected brain area," the authors write.

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