See What HealthDay Can Do For You
Contact Us

Early-Life Exposure to Antibiotics Linked to Atopic Dermatitis

Exposure in utero and during first year of life linked to increased risk for atopic dermatitis; attenuated in sibling-control analysis

eczema

TUESDAY, May 4, 2021 (HealthDay News) -- Exposure to antibiotics in utero and during the first year of life is associated with an increased risk for atopic dermatitis, with the correlation partially attenuated after adjustment for familial factors, according to a study published online April 29 in JAMA Network Open.

Mwenya Mubanga, M.D., Ph.D., from the Karolinska Institutet in Stockholm, and colleagues examined the correlation of exposure to antibiotics in the prenatal period and early childhood with the risk for atopic dermatitis. Data were analyzed for 722,767 singleton children born between March 1, 2006, and Dec. 31, 2010. To account for shared familial factors, a sibling-control analysis was conducted.

The researchers found that 21.2 and 23.8 percent of children were exposed to antibiotics in utero and during the first year of life, respectively. Compared with unexposed children, children exposed to prenatal antibiotics had a greater risk for atopic dermatitis (adjusted hazard ratio [aHR], 1.10; 95 percent confidence interval [CI], 1.09 to 1.22). No association was seen in the sibling-control analysis (aHR, 0.96; 95 percent CI, 0.92 to 1.00). The risk for atopic dermatitis was also increased with exposure to antibiotics during the first year of life (aHR, 1.52; 95 percent CI, 1.50 to 1.55), with associations attenuated in the sibling-control analysis (aHR, 1.24; 95 percent CI, 1.20 to 1.29).

"Further research should be conducted to determine the underlying mechanisms and the atopic dermatitis phenotypes that are more likely to be associated with other conditions, such as asthma and allergic rhinitis," the authors write.

One author disclosed financial ties to the biopharmaceutical industry.

Abstract/Full Text

Editorial

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.