Youth at Any Price: Growth Hormones and Aging

At this point, no one would dispute the link between growth hormone and aging. It's a fact that as we age, our bodies produce less of this important hormone. "It's natural human physiology to have a decline in the amount of growth hormone we produce as we get older," says Mary Lee Vance, an endocrinologist in Virginia who specializes in growth disorders.

Youth at any price

Since the link between aging and declining growth hormone was established, growth hormone has joined plastic surgery and botox as another weapon in the war against growing old. But experts disagree over the benefit of such treatment -- and many warn users that they could be putting their health at serious risk.

The debate started in 1990 when the late Daniel Rudman, MD, a researcher at the Medical College of Wisconsin, published a study in the New England Journal of Medicine showing that 12 elderly men who took growth hormone significantly increased their muscle mass, decreased their fat, and saw their skin thicken -- all changes associated with a more youthful metabolism.

Since then, growth hormone has become a growth industry. Vance estimates that more than a third of all growth hormone prescriptions are being written "off label" for those seeking anti-aging benefits. ("Off-label is the term used when a doctor prescribes a medication for a condition not on the Food and Drug Administration approval list.)

Ron Rothenberg, MD, who runs an anti-aging clinic in Encinitas, California, is one of the many doctors who consider growth hormone an effective anti-aging tool. "If we were all going to just stay the same, I'd say don't do anything," he says. "But we're not, we all suffer from this ugly, fatal disease called aging. So why not do something to treat it?"

Rothenberg, originally an emergency medicine doctor, has been taking growth hormone himself for five years and says there's no denying its benefits. "It's relatively subtle, it doesn't knock your socks off. But you notice you have more energy, feel more optimistic, your memory's better -- you feel like you did ten years ago."

But many question whether replenishing our stores of growth hormone to stave off aging is really worth the risk. For endocrinologist Mary Lee Vance, the answer is a vehement no. "Mother Nature is pretty smart," she insists. "There might be a reason for the decline [in growth hormone levels as we age] and we should leave well enough alone."

Vance recently wrote an editorial in the New England Journal of Medicine slamming internet companies that are currently trying to market growth hormone and substances said to stimulate growth hormone production.

Vance points out, "There have been some studies that have shown that growth hormone can bring about some beneficial changes in body composition and muscle mass but you can do the same thing at the gym. And without playing around with your endocrine system."

Vance cites the very real risks associated with elevated levels of growth hormone : edema, high blood pressure, aching joints, and carpel tunnel syndrome, as well as cardiovascular problems. Even more troubling is the possibility that growth hormone could make tumors grow more quickly.

"Growth hormone makes things grow, so it stands to reason that it could cause a tumor to grow more quickly than it otherwise would," says Dr. Anthony Karpas, an endocrinologist in Atlanta, Georgia, who specializes in treating growth disorders. Doctors treating growth hormone deficiency require patients to have been cancer-free for at least five years, and there is concern among endocrinologists that doctors prescribing growth hormone off label are not being as rigorous.

Anyone considering taking growth hormone should also be tested for diabetes, since 40 percent of adults on growth hormone develop diabetes or glucose intolerance, according to Dr. David Cook, an endocrinologist at Oregon Health and Science University.

"Growth hormone can aggravate insulin effects, so if you're already diabetic it may get worse," Cook says.

Finally, there's the concern that taking growth hormone could create a serious imbalance in your system. "If you give yourself growth hormone above normal levels, you could shut off your pituitary gland," says Vance. In fact, by doing so, taking growth hormone could achieve exactly the opposite of what you intend.

"People taking it for fountain of youth reasons may find that it's counterproductive," says Cook. Not only does an excess of growth hormone pose a serious cardiovascular risk, says Cook, but it can cause the body to get fatter rather than thinner. The body responds to excess growth hormone by producing more insulin, then overcompensates by depositing more fat.

The one thing that all growth hormone experts agree on -- even the anti-aging enthusiasts -- is that the supplements sold by health food companies over the Internet simply do not work. "The only thing that works is injectable human growth hormone," says Rothenberg. "The other stuff is all totally useless. It doesn't do anything."

Vance agrees, explaining that the supplements are taken orally and they cannot make it past the liver to affect the endocrine system.

Of most concern to endocrinologists is the long-term danger of artificially pumping up growth hormone levels. "The safety of taking growth hormone for fountain-of-youth reasons hasn't been studied properly," says Cook. "We just don't know what we might find out down the road."

References

Interview Ron Rothenberg, MD California Health Span Institute

Interview with Anthony Karpas, MD, endocrinologist

Interview with Mary Lee Vance, MD

Interview with David M. Cook, MD Endocrinologist American Association of Clinical Endocrinologists

National Institute of Health (NIH) Medline Database on Growth Disorders

Overview Article from the Nemours Foundation (linked from NIH/Medline)

Abstract of Psychological Effects of Withdrawal of Growth Hormone Therapy from Adults with Growth Hormone Deficiency McMillan CV, Bradley C, Gibney J, Healy ML, Russell-Jones DL, Sonksen PH. Clin Endocrinol (Oxf) 2003 Oct:59(4):467-75

Rudman D et al. Effects of human growth hormone in men over 60 years old. The New England Journal of Medicine. Volume 323, Number 1. July 5, 1990.

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