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Resveratrol Level Not Linked to Longevity in Older Adults

No association between urinary metabolite concentration and all-cause mortality

THURSDAY, May 15, 2014 (HealthDay News) -- Resveratrol levels in the diet do not appear to be associated with mortality or incidence of disease, such as cardiovascular disease or cancer, in older adults, according to research published online May 12 in JAMA Internal Medicine.

Richard D. Semba, M.D., M.P.H., of Johns Hopkins University in Baltimore, and colleagues conducted a prospective cohort study of 783 community-dwelling men and women aged 65 years and older. The authors sought to assess the relationship between resveratrol levels and cancer, cardiovascular disease, inflammation, and mortality.

The researchers found that, for quartiles of urinary resveratrol metabolites from lowest to highest, all-cause mortality was 34.4, 31.6, 33.5, and 37.4 percent, respectively (P = 0.67). After multivariable adjustment, participants in the lowest quartile versus the highest quartile of total urinary resveratrol had a hazard ratio for mortality of 0.80 (95 percent confidence interval, 0.54 to 1.17). No significant associations were found between urinary resveratrol levels and serum C-reactive protein, interleukin-6, interleukin-1β, tumor necrosis factor, cardiovascular disease (prevalent or incident), or cancer.

"In older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, or cancer or predictive of all-cause mortality," the authors write.

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