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Genetic Variant in Mexicans Affects Cholesterol, Obesity

Mexicans with variant are more likely to have low levels of high-density lipoprotein and be obese

FRIDAY, July 20 (HealthDay News) -- Mexican individuals with the R230C variant of the ATP-binding cassette transporter gene are more likely to have low levels of high-density lipoprotein (HDL) and be obese than their counterparts who do not have this variant, according to the results of a new study in the July issue of Diabetes.

Samuel Canizales-Quinteros, Ph.D., and colleagues from the Salvador Zubiran National Institute of Medical Sciences and Nutrition in Mexico City, Mexico, screened for the variant of the ATP-binding cassette transporter A1 (ABCA1) gene known as R230C to determine how it affected HDL cholesterol and other metabolic traits including body mass index in 429 Mexican individuals.

The R230C variant was found 20.1 percent of the participants. It was significantly associated with low HDL and apolipoprotein A-I levels as well as obesity (odds ratio 2.527), metabolic syndrome (OR, 1.893) and type 2 diabetes (OR, 4.527), the report indicates.

"Functional studies both in vitro and in vivo are required to further understand the role of ABCA1 and the R230C variant in these metabolic traits," the authors conclude.

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