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Silicone Implants Do Not Lead to Paraproteinemias

Study considers women with silicone implants who also have connective-tissue disease

FRIDAY, Sept. 21 (HealthDay News) -- Women with silicone implants who subsequently developed connective-tissue disease do not appear to be at increased risk for paraproteinemias, according to study findings published in Arthritis Research & Therapy in September.

Gyorgy Csako, M.D., of the National Institutes of Health in Bethesda, Md., and colleagues conducted a case-control study to investigate whether silicone implants increased the risk of paraproteinemias, apart from any contribution of connective-tissue disease (CTD). The researchers compared 74 women with silicone implants who subsequently developed CTD to 74 age- and CTD-matched women without silicone implants serving as controls.

Silicone implants were not associated with a statistically significant increase in paraproteinemia. However, women with silicone implants, either with or without CTD, had lower serum globulins and immunoglobulins than women in the control group.

"We found unexpected significant differences in the serum protein profiles of women with silicone implants compared to those without silicone implants, but no evidence for a substantially increased risk of paraproteinemia. From a public health point of view, silicone implants appear to have a minimal, if any, effect on the number of women in whom paraproteins may occur, even in the context of coexisting connective tissue disease," the authors conclude.

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