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MS Linked to Lower Survival After Breast Cancer Diagnosis

Risk for all-cause mortality increased, but no association seen between multiple sclerosis and cancer-specific survival


THURSDAY, May 20, 2021 (HealthDay News) -- For women with breast cancer, those with multiple sclerosis (MS) have an increased risk for all-cause mortality compared with those without MS, according to a study published online May 19 in Neurology.

Ruth Ann Marrie, M.D., Ph.D., from the University of Manitoba in Winnipeg, Canada, and colleagues identified female MS cases and linked MS cohorts to cancer registries to identify women with breast cancer. Four matched breast cancer controls without MS were selected; data were included for 779 MS cases and 3,116 controls with breast cancer. All-cause survival and cancer-specific survival were compared between cohorts.

Most of the patients with stage data were diagnosed with stage I or II breast cancer, with a mean age at diagnosis of 57.8 years. The researchers found that MS was associated with an increased risk for all-cause mortality (hazard ratio, 1.28; 95 percent confidence interval, 1.08 to 1.53) but was not associated with any difference in cancer-specific survival (hazard ratio, 0.98; 95 percent confidence interval, 0.65 to 1.46).

"Women with MS have lower survival after breast cancer than women without MS. A clear understanding of prognosis is important for clinical decision making, thus our findings provide information that may inform women with MS and their health care providers," the authors write. "Future studies should identify MS-specific factors associated with worse prognosis."

One author disclosed financial ties to F. Hoffmann-La Roche.

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