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New Chromosomal Loci Linked to Crohn's Disease

Researchers identify four new regions genetically associated with disease

WEDNESDAY, Sept. 12 (HealthDay News) -- Four chromosomal regions are associated with Crohn's disease, according to study findings published online Sept. 5 in the Proceedings of the National Academy of Sciences.

John V. Raelson, Ph.D., from Genizon BioSciences Inc., in St. Laurent, Canada, and colleagues performed a genome-wide association study for Crohn's disease using 382 family trios from the Quebec Founder Population, a genetically isolated group descended from French immigrants who settled in Quebec in the 16th century.

By examining over 164,000 evenly spaced chromosomal regions, the researchers found multiple regions associated with the disease. One region each on chromosome 3 and 4 and two regions of chromosome 17 were verified in two independent German populations.

"Together with previously published loci, the spectrum of Crohn's disease genes identified to date involves biochemical networks that affect epithelial defense mechanisms, innate and adaptive immune response, and the repair or remodeling of tissue," Raelson and colleagues conclude.

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