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Researchers Link More Gene Variants to Celiac Disease

Several single-nucleotide polymorphisms identified with association to disease predisposition

WEDNESDAY, March 26 (HealthDay News) -- Several single-nucleotide polymorphisms (SNPs) are newly associated with celiac disease, pinpointing novel determinants of predisposition to the disease, researchers report in the March issue of Gastroenterology.

Ainara Castellanos-Rubio from Hospital de Cruces in Barakaldo-Bizkaia, Spain, and colleagues genotyped 361 SNPs from 71 genes that had been linked to celiac disease by strict functional and positional criteria in 262 celiac disease patients and 214 controls.

The researchers found a significant association between celiac disease and several SNPs, some of which were located in previously identified linkage regions including SERPINE2 in 2q33, and PBX3 or PPP6C in 9q34. The researchers found the most significant SNPs were rs6747096, rs7040561 and rs458046.

"Are the genes they identified really involved in the pathogenesis of celiac disease? This is far from clear," Ludvig M. Sollid, M.D., from the University of Oslo and Rikshopitalet University Hospital in Oslo, Norway, writes in an accompanying editorial. "A concern underlying this study is the lack of replication in an independent cohort of patients and controls."

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