MONDAY, Oct. 18 (HealthDay News) -- Obesity and insulin resistance appear to be associated with an increased risk of non-cirrhotic hepatocellular carcinoma (HCC), with obesity also tied to an elevated risk of colorectal adenoma recurrence, according to two studies presented at the annual scientific meeting of the American College of Gastroenterology, held from Oct. 15 to 20 in San Antonio.
To assess the association of non-cirrhotic HCC with body mass index (BMI) and diabetes, Benjamin Mitlyng, M.D., of the University of Minnesota in Minneapolis, and colleagues evaluated 12 patients with non-cirrhotic HCC who underwent partial hepatectomy between January 2008 and September 2009. Despite a lack of steatosis, the investigators found that patients with non-cirrhotic HCC had a high prevalence of diabetes and elevated BMIs. However, despite the presence of advanced disease in some patients, those who underwent resection experienced minimal complications, tolerated the procedure well, had no operative mortality, and experienced an average tumor-free follow-up of 17.5 months.
As part of the Polyp Prevention Trial, Adeyinka Laiyemo, M.D., of the National Cancer Institute in Bethesda, Md., and colleagues evaluated the cumulative risk of colorectal adenoma recurrence associated with obesity. At baseline, about one-half of the 760 participants were overweight (BMI, 25 to 29 kg/m²) and one-fourth were obese (BMI, 30 kg/m²). Over a follow-up of 8.4 years, the investigators found that overweight and obese patients had an elevated risk of adenoma recurrence over both the short and long term.
"Since BMI was positively associated with adenoma recurrence in [the] short and long term, lifestyle modification should be encouraged," Laiyemo said in a statement.
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