See What HealthDay Can Do For You
Contact Us

Zinc Effective in Pediatric Presymptomatic Wilson Disease

Initial dose of 50 mg/day of zinc was effective for children under 6 years old

a child boy during an exam in a hospital

THURSDAY, May 4, 2017 (HealthDay News) -- For young children with presymptomatic Wilson disease, zinc monotherapy is safe and effective, according to a study published online April 28 in the Journal of Gastroenterology and Hepatology.

Keisuke Eda, from the Kurume University School of Medicine in Japan, and colleagues examined 24 children younger than 10 years with presymptomatic Wilson disease who received zinc monotherapy from the time of diagnosis.

The researchers observed a significant decrease in aspartate aminotransferase and alanine aminotransferase beginning one month after treatment initiation, and remaining under 50 U/L from one to eight years of treatment. At six months there was a significant decrease in 24-hour urinary copper, which usually remained under 75 µg/day and between 1 and 3 µg/kg/day for the rest of the study. Patients continued taking zinc and none of them became symptomatic. Aspartate aminotransferase and alanine aminotransferase significantly decreased at one month after treatment initiation in patients under 6 years who received 50 mg/day of zinc as an initial dose; at six months there were decreases in γ-glutamyltranferase and 24-hour urinary copper.

"To our knowledge, this is the first multicenter study of zinc monotherapy for young children with presymptomatic Wilson disease," the authors write. "Such monotherapy proved highly effective and safe."

Full Text (subscription or payment may be required)

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.