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Natural History of Esophageal Stricture Studied

Incidence of rare condition is decreasing, possibly because of increased proton pump inhibitor use

FRIDAY, Dec. 29 (HealthDay News) -- Esophageal stricture is a rare condition and its incidence has declined as proton pump inhibitor use has increased, according to a study published in the December issue of the American Journal of Gastroenterology.

Ana Ruigomez, M.D., Ph.D., of Centro Espanol de Investigacion Farmacoepidemiologica in Madrid, Spain, and colleagues analyzed 1994-2000 data from the U.K. General Practice Research Database and confirmed 536 cases of esophageal stricture, 68 percent of which were peptic.

The researchers found that esophageal stricture had an incidence of 1.1 per 10,000 person-years, which increased significantly with age. They also found that an increased risk of stricture was associated with prior dysphagia, gastroesophageal reflux disease, hiatus hernia, peptic ulcer disease and heavy alcohol use. Risk of recurrence associated with long-term proton pump inhibitor use adjusting for other factors was found to be 0.6.

"Incidence of stricture decreased from 1994 to 2000, concomitant with a substantial increase in proton pump inhibitor use," the authors write. "Further specific research is needed to confirm the relationship between these two trends."

Funding for this study provided by AstraZeneca.

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