See What HealthDay Can Do For You
Contact Us

Repeated FITs May Be Equivalent Alternative to Colonoscopy

Annual FIT IDs all colorectal cancer, equivalent number of advanced neoplasias

Repeated FITs May Be Equivalent Alternative to Colonoscopy

WEDNESDAY, Nov. 5, 2014 (HealthDay News) -- Repeated annual fecal immunochemical tests (FITs) can detect all colorectal cancer (CRC) cases and may be equivalent to colonoscopy in detecting advanced neoplasia in first-degree relatives of patients with CRC, according to a study published in the November issue of Gastroenterology.

Enrique Quintero, M.D., Ph.D., from Universidad de La Laguna in Spain, and colleagues randomized (1:1) 1,918 first-degree relatives of patients with CRC to receive a single colonoscopy examination (782 individuals) or three FITs (784 individuals; one/year for three years; using a cut-off ≥10 µg hemoglobin/g feces). An equivalency of the strategies was defined by a difference of the 95 percent confidence interval for the detection of advanced neoplasia of ±3 percent.

The researchers found that advanced neoplasia was detected in 4.2 percent of the FIT group and 5.6 percent of the colonoscopy group (odds ratio, 1.41; 95 percent confidence interval, 0.88 to 2.26; P = 0.14). In the FIT group, 3.9 percent of the first-degree relatives had advanced neoplasia, as did 5.8 percent in the colonoscopy group (odds ratio, 1.56; 95 percent confidence interval, 0.95 to 2.56; P = 0.08). While FIT did not miss CRC, it missed 16 of 41 advanced adenomas. Compared to the colonoscopy strategy, endoscopic evaluation was required in four-fold fewer individuals using the FIT strategy.

"Repeated FIT screening (one/year for three years) detected all CRCs and proved equivalent to colonoscopy in detecting advanced neoplasia in first-degree relatives of patients with CRC," the authors write. "This strategy should be considered for populations where compliance with FITs is higher than with colonoscopy."

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.