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Vitamin D, Calcium Don't Cut Recurrent Adenoma Risk

No decrease in colorectal adenomas seen with supplements, taken together or alone

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THURSDAY, Oct. 15, 2015 (HealthDay News) -- Supplemental vitamin D and calcium do not seem to reduce the risk of recurrent colorectal adenomas, according to a study published online Oct. 14 in the New England Journal of Medicine.

John A. Baron, M.D., from Dartmouth University in Hanover, New Hampshire, and colleagues randomly assigned 2,259 patients with recently diagnosed adenomas to receive daily vitamin D3 (1,000 IU), calcium as carbonate (1,200 mg), both, or neither. Follow-up colonoscopy was expected to be performed three or five years after the baseline examinations.

The researchers found that participants who received vitamin D had a mean net increase in serum 25-hydroxyvitamin D levels of 7.83 ng per milliliter compared with participants given placebo. During follow-up, 43 percent of participants had one or more adenomas diagnosed. The adjusted risk ratios for recurrent adenomas were 0.99 (95 percent confidence interval [CI], 0.89 to 1.09) for those taking vitamin D versus no vitamin D, 0.95 (95 percent CI, 0.85 to 1.06) for calcium versus no calcium, and 0.93 (95 percent CI, 0.8 to 1.08) for both agents versus neither agent.

"Daily supplementation with vitamin D3 (1,000 IU), calcium (1,200 mg), or both after removal of colorectal adenomas did not significantly reduce the risk of recurrent colorectal adenomas over a period of 3 to 5 years," conclude the authors.

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