Health Highlights: Sept. 24, 2006

Big Jump Seen in War Vets Suffering From Stress Possible New Approach to Stem-Cell Research Reported FDA Needs New Tools to Fix Drug System: Study ADHD Drug Misuse Tied to Higher ER Visits Drug-Resistant TB Gaining Ground in U.S.

Here are some of the latest health and medical news developments, compiled by the editors of HealthDay:

Big Jump Seen in War Vets Suffering From Stress

A new Veterans Health Administration report found that more than one-third of Iraq and Afghanistan veterans are now seeking medical treatment for stress or other mental disorders -- a ten-fold increase in the last 18 months, the Associated Press reported.

The surge in cases, which coincides with more troops facing multiple tours of duty in Iraq and Afghanistan to combat stubborn insurgency groups, has prompted some veterans organizations to say they're concerned the VA may not be able to meet the demand for mental-health services. They say veterans have had to contend with long waits for doctor appointments, staffing shortages, and lack of equipment at VA-run medical centers, the AP said.

On the plus side, VA and Defense Department officials said the increase in soldiers complaining of stress or mental-health problems may indicate that efforts to reduce the stigma of problems such as post-traumatic stress disorder are working. Also, commanders and medical personnel may be more skilled at recognizing symptoms.

VA officials say they've increased funding for mental-health services, have hired at least 100 more counselors, and aren't struggling to meet the rising demand, the AP said.

"We're not aware that people are having trouble getting services from us in any consistent way or pattern around the country," said Dr. Michael Kussman, acting undersecretary for health and the top doctor at the VA.


Possible New Approach to Stem-Cell Research Reported

European researchers say they may have come up with an alternative method of harvesting embryonic stem cells, one that doesn't require destruction of an embryo.

If the research proves successful, it could blunt criticism of embryonic stem-cell research, which opponents say leads to the destruction of human life.

The scientists, from Spain and England, said they created a stem-cell line from a human embryo that had stopped developing naturally in a laboratory setting. The researchers studied embryos donated by an in-vitro fertilization clinic with consent of the patients. Part of the research focused on 132 "arrested" embryos -- those that had stopped dividing for 24 or 48 hours after reaching various stages of development, the Associated Press reported.

Thirteen of those embryos had developed more than the others, reaching 16 to 24 cells before cell division stopped. The researchers were able to create a stem-cell line from just one of these embryos. But, these stem cells performed normally on a series of tests, Miodrag Stojkovic of the Prince Felipe Research Center in Valencia, Spain, told the AP.

The research was published online Thursday by the journal Stem Cells.

But opponents of stem-cell research said there's no way to know if an arrested embryo would have continued growing if it had been removed from a lab dish and placed into woman's womb, said Robin Lovell-Badge of the Medical Research Council's National Institute for Medical Research in London.

Many scientists believe that embryonic stem cells have the ability to develop into any cell type in the body. They envision a future where stem cells might help replace diseased or injured tissue, thereby treating a host of ailments.


FDA Needs New Tools to Fix Drug System: Study

The safety of the nation's drug supply is inadequate, and the U.S. Food and Drug Administration's oversight is beset with poor management, internal squabbling and chronic underfunding, according to a congressional advisory report released Friday.

The report by the Institute of Medicine, a nonprofit organization created by Congress to advise the federal government on health issues, was conducted at the FDA's request, the New York Times reported Friday.

Among the panel's recommendations, most of which would require Congressional authorization:

  • Drugs should only be approved for five-year periods so that the FDA can thoroughly review post-approval safety questions.
  • Newly approved drugs should display a black triangle on their labels to warn consumers that their safety is more uncertain than that of older drugs.
  • Drug advertisements should be banned during this initial period.
  • The FDA should be given the authority to issue fines, injunctions and withdrawals when drug makers fail to complete required safety studies.
  • The FDA commissioner should be appointed to a six-year term.

The report also suggested that one of the agency's biggest problems is a deal struck between Congress and the drug industry in 1992, in which drug makers agreed to pay millions in fees in order to speed reviews, and thereby increased pressures on drug reviewers to act quickly, the Times reported.

It is unlikely that Congress will act on the proposals before next year, when it must reauthorize the 1992 funding deal with the drug industry. Despite its strong words, however, the report, according to the Times, may actually bolster the confirmation prospects of Dr. Andrew von Eschenbach, who is now the FDA's acting commissioner.


ADHD Drug Misuse Tied to Higher ER Visits

Polydrug use -- taking at least one other drug in addition to medication for attention deficit hyperactivity disorder -- was a common factor in increased emergency room visits by those 12-to-17 years old and could lead to serious health problems such as heart attack or stroke, a new report from the Substance Abuse and Mental Health Services Administration (SAMHSA) shows.

In its latest "Drug Abuse Warning Network (DAWN) Report" released Friday, the agency found that emergency visits resulting from misuse of one drug or two drugs by teen patients were higher in 2004 than the rates for patients aged 18 or older. For patients aged 12 to 17 taking methylphenidate (Ritalin) for medical use, there were 1.6 visits to the emergency department per 100,000 people in this age group, compared to 0.4 visits per 100,000 people in the 18-to-24 age group.

For patients aged 12 to 17, taking amphetamine-dextroamphetamine for medical use, there were 1.2 visits per 100,000 people compared to 0.6 per 100,000 people in the 18-to-24 age group.

For all age groups reporting nonmedical use of ADHD medications, 32 percent ingested the ADHD medication alone. For the 68 percent using at least one additional drugs with the ADHD medication, 20 percent reported using alcohol, 26 percent used an illicit drug, and 57 percent used another pharmaceutical, the report found.


Drug-Resistant TB Gaining Ground in U.S.

The worst forms of tuberculosis bug have been gaining ground in the United States, and states with the highest numbers of multi-drug resistant cases in the last decade were New York, California, Texas and Florida, according to a new report by the U.S. Centers for Disease Control and Prevention.

What is alarming public health officials are imported drug-resistant strains of a disease that is mostly under control in this country but is being brought in by legal visitors. Often those with drug-resistant strains stop taking their medicine when they feel better but aren't cured, and health officials said that simply tightening immigration controls won't solve the problem, the Associated Press reported.

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