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Shorter Closure Time for in Vitro Adult Platelet Transfusion

Adult platelets lead to higher clot strength and firmness, compared to neonatal platelets

WEDNESDAY, March 23 (HealthDay News) -- Transfusion of adult platelets into neonatal blood results in shorter platelet function analyzer closure time compared with neonatal platelets, according to a study published online Feb. 14 in the Journal of Thrombosis and Haemostasis.

Francisca Ferrer-Marin, M.D., Ph.D., of the Children's Hospital Boston, and colleagues evaluated the effect of in vitro transfusion of adult platelets into neonatal blood. Platelet concentrates were generated from cord blood and adult peripheral blood. Adult and neonatal-derived platelet concentrates were transfused in vitro into thrombocytopenic cord and adult blood, and evaluated for the presence of a hypercoagulable profile.

The investigators found that there was improved aggregation in adult platelets compared to neonatal platelets in response to thrombin receptor-activating peptide, adenosine 5-diphosphate, and collagen irrespective of whether they were transfused into adult or cord blood. Transfusion of adult platelets into thrombocytopenic cord blood compared to neonatal platelets resulted in shorter platelet function analyzer closure time, increased clot strength, and firmness.

"While the clinical significance of our findings remains to be determined, our observations should raise awareness of the substantial differences between the neonatal and adult hemostatic system and of the potential 'developmental hemostatic mismatch' associated with platelet transfusions," the authors write.

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