Breast Cancer Diagnosed Later in Blacks Than Whites

Black women's tumors less likely to express estrogen receptor, more likely to have Ki-67

TUESDAY, July 10 (HealthDay News) -- Black women are often diagnosed with more-advanced breast cancers than white women, and their tumors are more likely to express Ki-67 and p53, and less likely to have estrogen receptors, according to a report published online July 9 in Cancer.

Gloria Morris, M.D., Ph.D., of Thomas Jefferson University Hospital in Philadelphia, and colleagues analyzed national breast cancer data from 197,274 black and white females, as well as data from 2,230 whites and blacks diagnosed at the hospital between 1995 and 2002.

The researchers found that black women were more likely than white women to be diagnosed with higher nuclear and histologic grade, and more advanced-stage tumors.

Fewer black women had estrogen-receptor positive tumors than whites (51.9 percent versus 63.1 percent). Black patients were more likely to have tumors that expressed Ki-67 (42.4 percent) and p53 (19.4 percent) than whites (28.7 percent and 13.1 percent, respectively) at all carcinoma stages.

"African-American patients with breast carcinomas are more likely than Caucasian patients to present with tumors that are of a later stage and higher grade, with higher Ki-67 expression and more estrogen receptor negativity, thereby highlighting a greater need for early screening among African-American women," the authors write.

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