Kaposi Sarcoma Lesions Predominately Multiclonal

The tumors are reactive proliferations, not malignancies, study findings suggest

TUESDAY, July 24 (HealthDay News) -- The majority of Kaposi sarcoma lesions are multiclonal in origin, and disseminated lesions are reactive proliferations rather than true malignancies, according to a report in the July 18 issue of the Journal of the National Cancer Institute.

Renan Duprez, Ph.D., of the Institut Pasteur in Paris, France, and colleagues used the HHV-8-fused terminal repeat as a marker, similar to techniques used to identify the clonal pattern of the Epstein-Barr virus, in their study of 139 Kaposi sarcoma biopsies from 98 patients of both sexes. The sample included 18 patients with disseminated lesions.

Of the 59 samples from which a clonal HHV-8 pattern could be determined (49 skin, nine lymph node, one tonsil), 11 were monoclonal (all skin) and 48, or nearly 80 percent of the sample, were multiclonal. Individual disseminated tumor skin lesions, the authors said, "were found to represent distinct expansions of HHV-8 infected spindle cells."

The evidence suggests that Kaposi sarcoma "is a multifocal disease, and all lesions do not arise from a single clone," according to an accompanying editorial.

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