See What HealthDay Can Do For You
Contact Us

R-CHOP Benefits Older Mantle-Cell Lymphoma Patients

Improved survival for older patients with R-CHOP induction, rituximab maintenance treatment

R-CHOP Benefits Older Mantle-Cell Lymphoma Patients

WEDNESDAY, Aug. 8 (HealthDay News) -- In older patients with mantle-cell lymphoma, a rituximab-based chemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone [R-CHOP]) followed by maintenance therapy with rituximab improves survival, according to a study published in the Aug. 9 issue of the New England Journal of Medicine.

Hanneke C. Kluin-Nelemans, M.D., Ph.D., from the University Medical Center Groningen in the Netherlands, and colleagues randomly assigned 560 patients (age 60 years and older; median age, 70 years) with mantle-cell lymphoma to six cycles of rituximab, fludarabine, and cyclophosphamide (R-FC) every 28 days or to eight cycles of R-CHOP every 21 days. Patients who responded were further randomized to maintenance treatment with rituximab or interferon alfa.

The researchers found that the R-FC and R-CHOP groups had similar complete remission rates (40 and 34 percent, respectively; P = 0.1). However, with R-FC there was more frequent progressive disease (14 versus 5 percent), a significantly lower four-year survival rate (47 versus 62 percent), and more patients died during the first remission (10 versus 4 percent). The frequency of grade 3 and 4 infections was balanced, and hematologic adverse effects were more frequent with R-FC than R-CHOP. For maintenance therapy, rituximab significantly reduced the risk of progression or death (hazard ratio, 0.55) and significantly improved four-year survival, compared with interferon-alfa, in patients who had responded to R-CHOP (87 versus 63 percent).

"R-CHOP induction followed by maintenance therapy with rituximab is effective for older patients with mantle-cell lymphoma," Kluin-Nelemans and colleagues conclude.

The study was partially supported by Roche Pharmaceuticals, Bayer Schering Pharma, and Schering-Plough; several authors disclosed financial ties to these and other pharmaceutical companies.

Full Text (subscription or payment may be required)

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.