Acquire the license to the best health content in the world
Contact Us

Lowest Dose of Aspirin Reduces Colorectal Cancer Risk

Regular use reduces risk in general population, with effects apparent after five years

THURSDAY, Sept. 16 (HealthDay News) -- Regular use of low-dose aspirin appears to reduce the risk of colorectal cancer (CRC) in the general population, which is evident after just five years of use, according to a study published online Sept. 15 in Gut.

In a population-based, case-control study, Farhat V.N. Din, of the University of Edinburgh in the United Kingdom, and colleagues assessed the relationship between nonsteroidal anti-inflammatory drug (NSAID) use and CRC risk among 2,279 individuals with CRC and 2,907 controls. NSAID intake was categorized as taking more than four tablets per week of low-dose aspirin (75 mg), non-aspirin NSAIDs (NA-NSAIDs), or any NSAID for more than a month.

The investigators found that 354 patients with CRC (15.5 percent) were taking low-dose aspirin compared with 526 controls (18.1 percent). Use of low-dose aspirin was associated with a lower risk of CRC (odds ratio, 0.78), which was apparent after one year. Cumulative dose analysis confirmed a decreased risk of CRC after five years of consistent use. The protective effect increased with duration of use. The investigators also found that use of NA-NSAIDs or any NSAID was inversely associated with CRC risk. However, NSAIDs did not have a demonstrable effect on all-cause or CRC-specific survival.

"This is the first study to demonstrate a protective effect against CRC associated with the lowest dose of aspirin (75 mg per day) after only five years [of] use in the general population. NSAID use prior to CRC diagnosis does not influence survival from the disease," the authors write.

Full Text (subscription or payment may be required)

Physician's Briefing