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Metabolic Syndrome and Obesity Up Risk of Mortality in CRC

Obese patients with metabolic syndrome have increased risk of all-cause, CRC-related death

digestive system

TUESDAY, Sept. 13, 2016 (HealthDay News) -- For patients with early-stage colorectal cancer (CRC), the presence of metabolic syndrome (MetSyn) and obesity is associated with increased risk of mortality, according to a study published online Sept. 6 in the Journal of Clinical Oncology.

Elizabeth M. Cespedes Feliciano, Sc.D., from Kaiser Permanente Northern California in Oakland, and colleagues studied 2,446 patients with early-stage CRC diagnosed from 2006 to 2011. Participants were classified according to the presence or absence of MetSyn and obesity.

The researchers found that 601 patients died over a median follow-up of six years, 325 as a result of CRC. For overall survival the hazard ratios were 1.45 for obese patients with MetSyn (95 percent confidence interval [CI], 1.12 to 1.82); 1.09 for non-obese with MetSyn (95 percent CI, 0.83 to 1.44); and 1.00 for obese patients without MetSyn (95 percent CI, 0.80 to 1.26), compared to non-obese patients without MetSyn. CRC-related survival was predicted by obesity with MetSyn (hazard ratio, 1.49; 95 percent CI, 1.09 to 2.02). There was an increase in the risk of death with the number of MetSyn components present, which was independent of obesity.

"Patients with early-stage CRC with obesity and MetSyn have worse survival, overall and CRC related," the authors write.

Two authors disclosed financial ties to the biopharmaceutical industry.

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