High-Fat Diet Tied to Certain Subtypes of Breast Cancer
High intake of saturated fat increases risk of HER2-negative, ER/PR-positive disease
MONDAY, April 14, 2014 (HealthDay News) -- High intake of saturated fats is associated with increased risk of certain subtypes of breast cancer, according to research published online April 9 in the Journal of the National Cancer Institute.
Sabina Sieri, Ph.D., of the Fondazione IRCCS Istituto Nazionale dei Tumori in Milan, and colleagues analyzed data from a prospective cohort of 337,327 women to assess the association between fat intake and development of breast cancer subtypes.
The researchers found that high intake of fat was associated with increased risk of estrogen receptor (ER)-positive, progesterone receptor (PR)-positive disease, but not ER-negative or PR-negative disease, for the highest versus lowest quintiles of total fat (hazard ratio [HR], 1.20; 95 percent confidence interval [CI], 1.00 to 1.45) and saturated fat (HR, 1.28; 95 percent CI, 1.09 to 1.52). High intake of saturated fat was associated with significantly greater risk of human epidermal growth factor 2 receptor (HER2)-negative disease.
"High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this breast cancer subtype," the authors write.