See What HealthDay Can Do For You
Contact Us

Low-Fat Diet Reduces Progression to Prostate Cancer

Reduces transition from prostatic intraepithelial neoplasia

THURSDAY, April 17 (HealthDay News) -- Reducing dietary fat can slow the transition from prostatic intraepithelial neoplasia to invasive prostate cancer in mice genetically prone to developing the disease, according to a report in the April 15 issue of Cancer Research.

Naoko Kobayashi, and colleagues from the University of California Los Angeles, examined the effect of a high-fat or low-fat diet (keeping calories equal) on the development of invasive prostate cancer in a transgenic mouse model of prostate cancer. The mice received the diet from 3 weeks of age, and the researchers note that the mice develop prostatic intraepithelial neoplasia at 2 to 4 weeks of age and invasive carcinoma at 6 to 9 months of age.

At 7 months of age, the investigators found that 27 percent fewer mice in the low-fat diet group developed invasive adenocarcinoma. Epithelial cells in intraepithelial neoplasias also proliferated significantly more slowly. Mice on the low-fat diet had significantly higher levels of serum insulin-like growth factor binding protein-1 as well as changes in cellular signaling molecules.

"Taken together, these studies suggest that reducing intake of dietary fat from corn oil may play a role in prostate cancer chemoprevention," Kobayashi and colleagues conclude.

Full Text (subscription or payment may be required)

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.