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Low-Fat Diet Reduces Progression to Prostate Cancer

Reduces transition from prostatic intraepithelial neoplasia

THURSDAY, April 17 (HealthDay News) -- Reducing dietary fat can slow the transition from prostatic intraepithelial neoplasia to invasive prostate cancer in mice genetically prone to developing the disease, according to a report in the April 15 issue of Cancer Research.

Naoko Kobayashi, and colleagues from the University of California Los Angeles, examined the effect of a high-fat or low-fat diet (keeping calories equal) on the development of invasive prostate cancer in a transgenic mouse model of prostate cancer. The mice received the diet from 3 weeks of age, and the researchers note that the mice develop prostatic intraepithelial neoplasia at 2 to 4 weeks of age and invasive carcinoma at 6 to 9 months of age.

At 7 months of age, the investigators found that 27 percent fewer mice in the low-fat diet group developed invasive adenocarcinoma. Epithelial cells in intraepithelial neoplasias also proliferated significantly more slowly. Mice on the low-fat diet had significantly higher levels of serum insulin-like growth factor binding protein-1 as well as changes in cellular signaling molecules.

"Taken together, these studies suggest that reducing intake of dietary fat from corn oil may play a role in prostate cancer chemoprevention," Kobayashi and colleagues conclude.

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