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Titanium Dioxide Nanoparticles Toxic in Mice

Study suggests nanoparticles associated with DNA damage and inflammation

THURSDAY, Dec. 3 (HealthDay News) -- Titanium dioxide nanoparticles, found in products such as paint and cosmetics, damage DNA and cause inflammation in mice, according to a study in the Nov. 15 issue of Cancer Research.

Benedicte Trouiller, Ph.D., and colleagues from the University of California in Los Angeles fed normal mice titanium dioxide nanoparticles in their drinking water, and assessed DNA damage and inflammation.

The researchers found that the nanoparticles induced several forms of DNA damage, including deletions, strand breaks and oxidative damage, as well as chromosomal damage. The nanoparticles also induced inflammation, as assessed by cytokine production.

"Together, these results describe the first comprehensive study of titanium dioxide nanoparticles-induced genotoxicity in vivo in mice possibly caused by a secondary genotoxic mechanism associated with inflammation and/or oxidative stress," Trouiller and colleagues conclude.

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