AACR: Black Raspberries Beneficial in Barrett's Esophagus
Raspberries modulate markers of oxidative stress, may help prevent esophageal cancer
THURSDAY, Dec. 6 (HealthDay News) -- In patients with Barrett's esophagus, dietary consumption of black raspberries may modulate markers of oxidative stress, according to research presented this week at the American Association for Cancer Research's Sixth International Conference on Frontiers in Cancer Prevention Research in Philadelphia.
John Fromkes, M.D., of Ohio State University in Columbus, and colleagues conducted a pilot study during which 20 patients received daily dosages of either 32 grams (women) or 45 grams (men) of lyophilized black raspberries for six months.
The researchers found that mean urine concentrations of 8-Iso-PGF2α, a marker of oxidative stress, declined from 1.59E-10 mg/mL at baseline to 1.30E-10 mg/mL at six months. The investigators also found that 58 percent of patients had dramatic individual declines in 8-Iso-PGF2α. In a subset of patients, they observed significant increases in tissue levels of the phase II enzyme GSTπ.
"These results are encouraging and support conducting a randomized, placebo-controlled trial in this patient cohort to more fully assess lyophilized black raspberries as inhibitors of esophageal adenocarcinogenesis," the authors conclude.