Lifestyle Changes Lead to Benefits in Prostate Cancer

Men with low-risk prostate cancer have changes at molecular level after nutrition and lifestyle intervention

WEDNESDAY, June 18 (HealthDay News) -- Men with low-risk prostate cancer who undertake an intensive nutrition and lifestyle intervention have beneficial changes at the molecular level in the prostate, according to the results of a study in the June 17 issue of the Proceedings of the National Academy of Sciences.

Dean Ornish, M.D., from the Preventive Medicine Research Institute in Sausalito, Calif., and colleagues profiled gene expression in the prostates of 30 men with low-risk prostate cancer, before and three months after they made changes in nutrition and lifestyle. The patients had declined conventional treatment, such as immediate surgery or radiation.

The researchers found that 48 genes were up-regulated and 453 genes were down-regulated after the changes, including genes critical in tumorigenesis, involved in protein metabolism and modification, intracellular protein traffic and protein phosphorylation.

"Intensive nutrition and lifestyle changes may modulate gene expression in the prostate," Ornish and colleagues conclude. "Understanding the prostate molecular response to comprehensive lifestyle changes may strengthen efforts to develop effective prevention and treatment."

Ornish has written books on preventive medicine, consults with food companies on healthy food products, and has received lecture honoraria on the topic.

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