Multiple Myeloma Family Merits Long-Term Follow-Up

Pattern of disease points to autosomal dominant transmission

WEDNESDAY, July 9 (HealthDay News) -- Five cases of multiple myeloma, three of monoclonal gammopathy of undetermined significance (MGUS) and five cases of prostate cancer across two generations of one family points to a pattern consistent with autosomal dominant transmission and warrants on-going study of the family, according to an article published in the July 10 issue of the New England Journal of Medicine.

Henry T. Lynch, M.D., of Creighton University School of Medicine in Omaha, Neb., and colleagues used detailed medical histories obtained from the family members via questionnaires and interviews. Cancer histories were confirmed where possible using original pathology reports or death certificates. They recruited the offspring and siblings of family members affected by myeloma and first-degree relatives of the identical twin of a myeloma-affected family member for evaluation of MGUS.

The putative progenitor, who died of colon cancer at age 88, fathered children with two women, and progeny from both developed multiple myeloma, the investigators report. All family members who developed multiple myeloma, MGUS or prostate cancer were in the putative progenitor's direct line of descent, the report indicates.

"This myeloma-prone family merits long-term medical and genetic follow-up, including formal linkage analysis, in search of a cancer-susceptibility locus," the authors write.

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