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Evidence Grows for Prostate Cancer Link at 8q24

Three polymorphisms at chromosome 8q24 identified as independent risk factors among men of European American ancestry

THURSDAY, Oct. 11 (HealthDay News) -- Three single-nucleotide polymorphisms (SNPs) that are associated with an increased risk of prostate cancer in European American men have been identified at human chromosome 8q24, researchers report in the Oct. 17 issue of the Journal of the National Cancer Institute.

Siqun Lilly Zheng, M.D., of Wake Forest University School of Medicine in Winston-Salem, N.C., and colleagues evaluated 1,563 prostate cancer patients of European descent, including 1,017 who were diagnosed with aggressive disease and 576 controls. Eighteen SNPs at 8q24 were selected for genotype analysis and results were compared to those in the National Cancer Institute's Cancer Genetic Markers of Susceptibility (CGEMS) database.

Statistically significant differences in allele frequencies between case and control subjects were observed at three loci. Four consecutive SNPs were observed in linkage disequilibrium with a previously reported risk-associated SNP at rs1447295. An independent, novel prostate cancer risk in linkage equilibrium with those four SNPs was observed at rs6983267. Comparison of data from this study with CGEMS data identified a third statistically significant locus associated with prostate cancer risk, at rs10086908.

An accompanying editorial by Sharon A. Savage, M.D., and Mark H. Greene, M.D., of the National Cancer Institute in Rockville Md., concludes, "As the evidence supporting associations between 8q24 genetic variants and an increased risk [of] prostate cancer accumulates, we will have a better understanding of the functional role of these SNPs and the population attributable risk that they confer."

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