Genetics Linked to Increased Lung Cancer Risk

Polymorphisms in untranslated regions of ABCB1, ABCC1 linked to increased risk

FRIDAY, Dec. 26 (HealthDay News) -- Two common polymorphisms in the 3' untranslated regions of adenosine triphosphate-binding cassette B1 and C1 (ABCB1 and ABCC1) are linked to a greater risk of developing lung cancer, according to research published online Dec. 23 in Cancer.

Haijian Wang, Ph.D., of Fudan University in Shanghai, China, and colleagues genotyped six common regulatory single-nucleotide polymorphisms of ABCB1 and ABCC1, using blood samples from 500 patients with lung cancer and 517 controls without lung cancer. ABCC1 has been shown to be involved in the elimination of metabolites of the tobacco carcinogen NNK, and ABCB1 removes harmful agents in the lungs.

The investigators report that people with the variant allele of ABCB1 rs3842 or ABCC1 rs212090 had a higher risk of lung cancer (odds ratios 1.36 and 1.37, respectively).

"ABC transporters are recognized increasingly for their ability to modulate the absorption, distribution, metabolism, excretion, and toxicity of xenobiotics. In addition to their originally revealed role in multidrug resistance in chemotherapeutics, there is cumulating evidence that these efflux pumps are capable of transporting a vast and chemically diverse array of toxicants, including dietary and environmental carcinogens, and, thus, are supposed to play an important role in preventing the accumulation of potentially harmful xenobiotics in sensitive tissues such as the lung," the authors write.

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