See What HealthDay Can Do For You
Contact Us

Immunotherapy Combo Treats Advanced Kidney Cancer

First results show survival benefit with nivolumab plus cabozantinib versus sunitinib


FRIDAY, Oct. 2, 2020 (HealthDay News) -- Nivolumab combined with cabozantinib is superior to sunitinib alone for the treatment of advanced clear cell renal cell carcinoma, according to a study presented at the annual meeting of the European Society for Medical Oncology, held virtually from Sept. 19 to 21.

Toni K. Choueiri, M.D., from the Dana-Farber Cancer Institute in Boston, and colleagues conducted a phase 3 randomized trial evaluating the checkpoint inhibitor nivolumab plus the tyrosine kinase inhibitor cabozantinib (323 patients) versus sunitinib (328 patients) for first-line treatment of advanced clear cell renal cell carcinoma.

During a median follow-up of 18.1 months, the researchers found that all three efficacy end points were met. Compared with sunitinib, nivolumab + cabozantinib significantly improved progression-free survival (hazard ratio, 0.51; median, 16.6 versus 8.3 months) and overall survival (hazard ratio, 0.60). Results were consistent across prespecified International Metastatic RCC Database Consortium risk and programmed death ligand 1 expression subgroups. With nivolumab + cabozantinib, the objective response rate was significantly higher compared with sunitinib (55.7 versus 27.1 percent), and a higher percentage of patients achieved complete response (8.0 versus 4.6 percent). Any-grade treatment-related adverse events occurred in 96.6 percent of patients treated with nivolumab + cabozantinib and 93.1 percent of patients treated with sunitinib (60.6 and 50.9 percent for grade ≥3, respectively).

"These results, along with manageable toxicity and superior health-related quality of life, highlight this regimen's potential importance among combinations of immunotherapies and tyrosine kinase inhibitors," Choueiri said in a statement.

The research was funded by Bristol Myers Squibb, Ono Pharmaceutical Co., Exelixis, Ipsen, and Takeda.

Press Release
More Information

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.