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American Association for Cancer Research, Dec. 5-8, 2007

Sixth Annual International Conference on Frontiers in Cancer Prevention Research

The American Association for Cancer Research's Sixth Annual International Conference on Frontiers in Cancer Prevention Research took place Dec. 5-8 in Philadelphia, and presented cutting-edge research in basic, clinical, epidemiologic and behavioral science.

"The major theme of the meeting is that prevention science is really growing," said Scott Lippman, M.D., of the University of Texas M.D. Anderson Cancer Center in Houston, program chair of the 2006 meeting and chair of an educational session at the 2007 meeting.

Martin Blaser, M.D., of the New York University School of Medicine, co-chaired a plenary session on "Understanding and Preventing Cancers Due to Microbes" and spoke on treating Helicobacter pylori infections as a way to help prevent gastric cancers. "About 20 percent of cancers are related to infections, including liver cancers caused by hepatitis B and cervical cancers caused by human papillomavirus (HPV)," Lippman said.

"Cervical cancer isn't the only cancer related to HPV," said Adriana Albini, Ph.D., of IRCCS Multimedica in Milan, Italy, a member of the meeting's program committee. "Others include anal and oral-pharyngeal cancers. So we're pushing for the HPV vaccine to be used in males as well as females. Widespread use of the vaccine could eradicate HPV."

Frank Meyskens, M.D., of the Chao Family Comprehensive Cancer Center in Orange, Calif., presented new research on difluoromethylornithine (DFMO), which irreversibly inhibits ornithine decarboxylase. He and his colleagues conducted a Phase III trial and found that the combination of DFMO and sulindac reduced tissue levels of polyamines in ways that led to a dramatic reduction in the recurrence of neoplastic colon polyps. "This is a major finding and will go on to be studied further in larger-scale trials," Lippman said.

Multiple presentations addressed the potential of natural substances to help prevent a wide range of cancers. One of the highlights, Albini said, was a presentation by John Pezzuto, M.D., of the University of Hawaii, who spoke on "The Isolation and Evaluation of Natural Product Chemopreventive Agents." Pezzuto addressed the potential of well-studied food derivatives such as resveratrol and discussed a novel battery of assays that have helped him and his team identify potentially new chemopreventive agents, such as two unusual bicyclic polyketides obtained from the marine actinomycete Salinispora arenicola.

"There is a lot more ocean than land, so it's likely that such research will lead to the discovery of many new marine chemopreventive agents," Albini said.

AACR: Diet, Physical Activity Affect Lung Cancer Risk

FRIDAY, Dec. 7 (HealthDay News) -- In never, former and current smokers, a healthy diet and physical activity may help reduce the risk of lung cancer, according to research presented this week at the American Association for Cancer Research's Sixth International Conference on Frontiers in Cancer Prevention Research in Philadelphia.

Abstract #B143

AACR: Weight Gain May Affect Breast Cancer Survival

FRIDAY, Dec. 7 (HealthDay News) -- Women who gain a significant amount of weight after a breast cancer diagnosis may have an increased risk of breast cancer death, and the risk is especially elevated in obese women, according to research presented this week at the American Association for Cancer Research's Sixth International Conference on Frontiers in Cancer Prevention Research in Philadelphia.

Abstract #A103

AACR: Antioxidant Cocktail Inhibits Prostate Cancer

THURSDAY, Dec. 6 (HealthDay News) -- Blueberry Punch -- an antioxidant-rich fruit juice concentrate containing blueberry, red grapes, raspberry, elderberry, grape seed and skin extract, citrus skin extracts, green tea extract, olive leaf/olive pulp extracts, tarragon, turmeric and ginger -- helps suppress prostate cancer growth, according to research presented this week at the American Association for Cancer Research's Sixth International Conference on Frontiers in Cancer Prevention Research in Philadelphia.

Abstract #A104

AACR: Diet May Help Reduce Risk of Bladder Cancer

THURSDAY, Dec. 6 (HealthDay News) -- Broccoli extract and raw cruciferous vegetables may help protect against bladder cancer, according to research presented this week at the American Association for Cancer Research's Sixth International Conference on Frontiers in Cancer Prevention Research in Philadelphia.

Abstract #B149
Abstract #B47 or PR-3

AACR: Black Raspberries Beneficial in Barrett's Esophagus

THURSDAY, Dec. 6 (HealthDay News) -- In patients with Barrett's esophagus, dietary consumption of black raspberries may modulate markers of oxidative stress, according to research presented this week at the American Association for Cancer Research's Sixth International Conference on Frontiers in Cancer Prevention Research in Philadelphia.

Abstract #B34

Physician's Briefing
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