See What HealthDay Can Do For You
Contact Us

April 2012 Briefing - Hematology & Oncology

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for April 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Screening Benefits Women in 40s With High Breast CA Risk

MONDAY, April 30 (HealthDay News) -- Women in their 40s, with at least a two-fold increased risk of breast cancer, benefit from biennial screening mammography; and having extremely dense breasts or first-degree relatives with breast cancer is associated with a two-fold increased risk of breast cancer for women in their 40s, according to two studies published in the May 1 issue of the Annals of Internal Medicine.

Abstract - van Ravesteyn
Full Text (subscription or payment may be required)
Abstract - Nelson
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Votrient Approved to Treat Advanced Soft Tissue Sarcoma

FRIDAY, April 27 (HealthDay News) -- Votrient (pazopanib) has been approved by the U.S. Food and Drug Administration to treat people with advanced soft tissue sarcoma who have received previous chemotherapy.

Medline Plus

Cancer Worry Linked to Continued Symptom Burden

FRIDAY, April 27 (HealthDay News) -- Age, fatigue, symptom burden, and risk perception are significantly associated with greater cancer worry three years after completing adjuvant treatment for breast cancer, according to a study published online March 15 in Psycho-Oncology.

Abstract
Full Text (subscription or payment may be required)

Excessive Neutropenia for Weekly Everolimus + Docetaxel

FRIDAY, April 27 (HealthDay News) -- For patients with metastatic breast cancer, weekly treatment with everolimus plus docetaxel every three weeks results in dose-limiting neutropenia and variable clearance of both drugs, according to a phase 1 study published in the May 1 issue of Cancer.

Abstract
Full Text (subscription or payment may be required)

Nutrition, Exercise Guidelines Updated for Cancer Survivors

THURSDAY, April 26 (HealthDay News) -- The American Cancer Society has updated the 2006 guidelines to provide new evidence and clinical practices related to nutrition and physical activity for cancer survivors during the continuum of cancer care, according to a report published online April 26 in CA: A Cancer Journal for Clinicians.

Abstract
Full Text

Subtype Best Predictor of Basal Cell Carcinoma Invasion Depth

THURSDAY, April 26 (HealthDay News) -- Basal cell carcinoma (BCC) subtype identified on biopsy and excision specimens is the best predictor of depth of invasion, according to a study published online April 16 in the Journal of the American Academy of Dermatology.

Abstract
Full Text (subscription or payment may be required)

Age, Life Expectancy Influence Termination of PSA Screening

THURSDAY, April 26 (HealthDay News) -- Most primary care providers consider both a man's age and life expectancy in deciding whether to discontinue prostate-specific antigen (PSA) screenings, but multiple factors are involved in this decision, according to a study published online April 19 in Cancer.

Abstract
Full Text (subscription or payment may be required)

Thiazolidinediones Tied to Lower Cancer Risk in Diabetes Patients

THURSDAY, April 26 (HealthDay News) -- Thiazolidinediones are associated with a lower risk of liver and colorectal cancer in patients with type 2 diabetes, according to a study published in the May issue of Hepatology.

Abstract
Full Text (subscription or payment may be required)

Adjuvant Therapy Shows Promise in Biliary Tract Cancer

THURSDAY, April 26 (HealthDay News) -- For patients with biliary tract cancers, postresection adjuvant therapy with chemotherapy or chemoradiotherapy appears to be beneficial in treating patients with biliary tract cancers, with significant improvement seen for patients with node or margin positivity, according to research published online April 23 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Erosive, but Not Nonerosive, GERD Ups Esophageal CA Risk

WEDNESDAY, April 25 (HealthDay News) -- Patients with gastroesophageal reflux disease with a history of esophagitis are at increased risk for esophageal adenocarcinoma, although the absolute risk is low, according to a study published in the May issue of Clinical Gastroenterology and Hepatology.

Abstract
Full Text (subscription or payment may be required)

No Benefit of Induction Chemo, High-Dose Boost in Anal Cancer

WEDNESDAY, April 25 (HealthDay News) -- Neither induction chemotherapy (ICT) nor high-dose radiation boost is associated with an improvement in five-year colostomy-free survival (CFS) in patients with locally advanced anal canal carcinoma (LAACC), according to a study published online April 23 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Warfarin Keeps Stroke Risk Low in Patients With A-Fib

WEDNESDAY, April 25 (HealthDay News) -- Use of warfarin for stroke prevention in patients with nonvalvular atrial fibrillation (AF) is associated with a low risk of stroke or systemic embolism, according to a meta-analysis published in the April 23 issue of the Archives of Internal Medicine.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

High Survival With Surgery in Low-Risk Neuroblastoma

WEDNESDAY, April 25 (HealthDay News) -- Surgery alone results in high five-year event-free and overall survival (EFS and OS) rates for patients with low-risk stage 2a and 2b neuroblastoma (NBL), according to research published online April 23 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Bladder Cancer Diagnosis Encourages Smokers to Quit

MONDAY, April 23 (HealthDay News) -- Smokers with a new diagnosis of bladder cancer are significantly more likely to quit compared with smokers in the general population, according to a study published online April 23 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Pediatric Regimen Beats Adult Chemo for Young Adults With ALL

MONDAY, April 23 (HealthDay News) -- Adolescent and young adult patients with acute lymphoblastic leukemia (ALL) who are treated with pediatric-inspired regimens exhibit lower all-cause mortality, higher complete remission and event-free survival rates, and lower relapse rates compared with those treated with conventional adult-chemotherapy regimens, according to a study published in the May issue of the American Journal of Hematology.

Abstract
Full Text (subscription or payment may be required)

CDC: HPV-Associated Cancers Strike More Than 30,000 Yearly

THURSDAY, April 19 (HealthDay News) -- Cancers associated with the human papillomavirus (HPV) are diagnosed in nearly 11 out of 100,000 men and women in the United States annually, and HPV vaccines play an important role in reducing the incidence of those cancers for which screening is not approved, according to a report published in the April 20 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

Full Text

Chemoradiotherapy Combo Ups Bladder Cancer Control

WEDNESDAY, April 18 (HealthDay News) -- Locoregional control of muscle-invasive bladder cancer is significantly improved with a treatment regimen consisting of radiotherapy and concurrent chemotherapy with mitomycin C and fluorouracil, according to a phase 3 study published in the April 19 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

New Treatment Offers Benefit for Hypoxic Laryngeal Tumors

WEDNESDAY, April 18 (HealthDay News) -- For patients with squamous cell laryngeal cancer, regional control rates are improved with accelerated radiotherapy (AR) plus carbogen inhalation and nicotinamide (ARCON) treatment compared with AR-alone, with the improvement seen in patients with hypoxic tumors, according to research published online April 16 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)
Editorial

Study Looks at Patient Perception of Harm During Cancer Care

WEDNESDAY, April 18 (HealthDay News) -- Cancer patients may often experience what they believe to be a preventable, harmful event during the diagnosis or treatment of their cancer, but rarely do they formally report these events, according to research published online April 16 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)
Editorial

Fewer Complications With IMRT for Prostate Cancer

TUESDAY, April 17 (HealthDay News) -- For patients with nonmetastatic prostate cancer, treatment with intensity-modulated radiation therapy (IMRT) is associated with fewer complications than proton therapy or conformal radiation therapy, according to a study published in the April 18 issue of the Journal of the American Medical Association, a theme issue on comparative effectiveness research.

Abstract
Full Text (subscription or payment may be required)

Nutrition, Mobility Predict Early Death in Elderly Cancer Patients

TUESDAY, April 17 (HealthDay News) -- Low nutritional assessment scores, poor mobility, and advanced disease predict early death after chemotherapy initiation among elderly patients with cancer, according to a study published online April 16 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

2001 to 2006 Saw Increase in Mohs Surgery for Skin Cancer

TUESDAY, April 17 (HealthDay News) -- For Medicare beneficiaries, the rate of use of Mohs micrographic surgery (MMS) to treat nonmelanoma skin cancer (NMSC) doubled from 2001 through 2006, according to research published in the April issue of the Archives of Dermatology.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Gender, BMI Impact Bladder Perforation During Resection

MONDAY, April 16 (HealthDay News) -- For patients with bladder tumors, female gender, low body mass index, and tumor characteristics correlate with the risk of bladder perforation during transurethral resection, according to research published in the May issue of The Journal of Urology.

Abstract
Full Text (subscription or payment may be required)

Herbal Carcinogen Linked to Urothelial Cancer in Taiwan

FRIDAY, April 13 (HealthDay News) -- A carcinogen produced by Aristolochia plants, which are commonly used in herbal remedies in Taiwan, is associated with signature types of DNA damage linked to aristolochic acid in Taiwanese patients with urothelial carcinoma of the upper urinary tract (UUC), according to a study published online April 9 in the Proceedings of the National Academy of Sciences.

Abstract
Full Text

Crizotinib Treatment Lowers Total Testosterone Levels

FRIDAY, April 13 (HealthDay News) -- Men with non-small-cell lung cancer (NSCLC) treated with crizotinib exhibit rapid suppression of total testosterone (T) levels compared with those who do not receive crizotinib treatment, according to research published online April 4 in Cancer.

Abstract
Full Text
Editorial

Most Breast Cancer Survivors Experience Lasting Side Effects

FRIDAY, April 13 (HealthDay News) -- The majority of breast cancer survivors experience one or more treatment-related side effects, and the proportion remains stable at six years post-diagnosis, according to a study published in a special supplement to the April 15 issue of Cancer addressing the physical late effects of breast cancer treatment.

Abstract
Full Text

Genes Identified for Ovarian Cancer Prognosis

FRIDAY, April 13 (HealthDay News) -- Bimodal genes, or molecular on/off switches, can distinguish clinically relevant subtypes of ovarian cancer and provide ideal targets for diagnostic and prognostic testing, according to a study published online April 11 in the Journal of Molecular Diagnostics.

Abstract
Full Text (subscription or payment may be required)

Copy Number Variants Tied to Increased Prostate Cancer Risk

THURSDAY, April 12 (HealthDay News) -- Copy number variants (CNVs) of two loci are linked to a significantly higher risk of prostate cancer, according to a study published online April 10 in the Proceedings of the National Academy of Sciences.

Abstract
Full Text (subscription or payment may be required)

Decreased Cancer Risk for Patients With PolyQ Diseases

THURSDAY, April 12 (HealthDay News) -- Patients with polyglutamine (polyQ) diseases have reduced incidence of cancer, according to a study published online April 12 in The Lancet Oncology.

Abstract
Full Text (subscription or payment may be required)

Heterogeneity Characterizes Induction Failure in Child ALL

WEDNESDAY, April 11 (HealthDay News) -- Induction failure in pediatric acute lymphoblastic leukemia (ALL) is characterized by biologic and clinical heterogeneity, according to a study published in the April 12 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Smoking Found to Be a Risk Factor for Barrett's Esophagus

WEDNESDAY, April 11 (HealthDay News) -- Cigarette smoking may be a modifiable risk factor for Barrett's esophagus, according to a study published in the April issue of Gastroenterology.

Abstract
Full Text (subscription or payment may be required)

Perception of Breast Cancer Care Differs From Actual Care Quality

WEDNESDAY, April 11 (HealthDay News) -- The perception of care for women living in inner cities with newly diagnosed, early-stage breast cancer is dependent, in large part, on factors other than the actual quality of care provided, including the quality of the process of getting care, trust in the physician, and perceptions of racism, according to research published online April 9 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

BMD Loss Occurs Early in Androgen Deprivation Therapy

WEDNESDAY, April 11 (HealthDay News) -- The highest average change in bone mineral density (BMD) occurs during early treatment of nonmetastatic, hormone-sensitive prostate cancer in men receiving intermittent androgen deprivation therapy (ADT), according to research published online April 9 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Injectable Contraceptive Linked to Elevated Breast Cancer Risk

TUESDAY, April 10 (HealthDay News) -- Recent use of the injectable contraceptive depo-medroxyprogesterone acetate (DMPA) for 12 months or longer may approximately double the risk of breast cancer in young women, according to a study published online Feb. 27 in Cancer Research.

Abstract
Full Text (subscription or payment may be required)

Strategy of Offering Choice of CRC Screening Ups Adherence

TUESDAY, April 10 (HealthDay News) -- Adherence to colorectal cancer (CRC) screening varies based on the screening strategy, with adherence linked to patient preference and ethnicity/race, according to a study published in the April 9 issue of the Archives of Internal Medicine.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Frequent, Older Dental X-Rays Linked to Brain Cancer

TUESDAY, April 10 (HealthDay News) -- Frequent bitewing or panorex dental X-rays taken on previous generations of machines are linked to an increased risk of intracranial meningioma, according to a study published online April 10 in Cancer.

Abstract
Full Text (subscription or payment may be required)

Insurers Should Screen Older Smokers for Lung Cancer

TUESDAY, April 10 (HealthDay News) -- Lung cancer screening with low-dose spiral computed tomography could be of substantial value in high-risk smoker populations over the age of 50, and commercial insurers should consider providing coverage for the screening, according to a study published in the April issue of Health Affairs.

Abstract
Full Text (subscription or payment may be required)

Tivozanib Exhibits Antitumor Activity in Renal Cancer

TUESDAY, April 10 (HealthDay News) -- The potent, selective vascular endothelial growth factor receptor-1, -2, and -3 inhibitor, tivozanib, demonstrates antitumor activity and is well tolerated in patients with advanced/metastatic renal cell carcinoma (RCC), according to research published online April 9 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Early Response Is an Indicator for Rectal Cancer Survival

TUESDAY, April 10 (HealthDay News) -- In patients with locally advanced rectal cancer undergoing radical resection, response to neoadjuvant chemoradiotherapy is an early marker that correlates with rates of recurrence-free survival, distant metastases, and local recurrences, according to research published online April 9 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Somatic Mutations in Two Genes ID'd in Stomach Cancer

MONDAY, April 9 (HealthDay News) -- Somatic mutations have been identified in two genes, FAT4 and ARID1A, involved in cell adhesion and chromatin remodeling in some patients with stomach cancer, according to a study published online April 8 in Nature Genetics.

Abstract
Full Text (subscription or payment may be required)

High U.S. Cancer Care Costs Seem to Be Worth It

MONDAY, April 9 (HealthDay News) -- For patients with cancer in the United States, the value of additional survival gains have exceeded the additional costs of U.S. health spending compared with European counties, according to a study published in the April issue of Health Affairs.

Abstract
Full Text (subscription or payment may be required)

Teen Alcohol Consumption Tied to Benign Breast Disease

MONDAY, April 9 (HealthDay News) -- Adolescent alcohol consumption is associated with increased risk of proliferative benign breast disease (BBD), which is a risk factor for breast cancer, and there is no evidence that adolescent folate intake provides a protective effect against alcohol-associated BBD, according to a study published online April 9 in Pediatrics.

Abstract
Full Text (subscription or payment may be required)

Statins Moderate Effect of Metformin on Prostate Cancer

MONDAY, April 9 (HealthDay News) -- For men with type 2 diabetes treated with metformin, prostate cancer (PCa) incidence varies depending on statin use, with a significantly reduced risk for patients taking a combination of metformin and statins, according to a study published online March 28 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Full Weight-Based Chemo Doses Recommended for Obese

THURSDAY, April 5 (HealthDay News) -- The American Society of Clinical Oncology Clinical Practice Guideline on Appropriate Chemotherapy Dosing for Obese Adult Patients With Cancer recommends using full weight-based cytotoxic chemotherapy doses to treat obese patients with cancer, according to an overview published online April 2 in the Journal of Clinical Oncology.

Abstract
Full Text

Increased Breast Cancer Risk With False-Positive Test

THURSDAY, April 5 (HealthDay News) -- Women with false-positive mammogram tests remain at significantly higher risk of breast cancer for six or more years, compared to women with negative tests, but the size of the excess risk has decreased since the early 2000s, according to a study published online April 5 in the Journal of the National Cancer Institute.

Abstract
Full Text (subscription or payment may be required)

Addition of Gemtuzumab Ozogamicin Ups Survival in AML

THURSDAY, April 5 (HealthDay News) -- For patients with untreated de novo acute myeloid leukemia, the addition of gemtuzumab ozogamicin to standard frontline chemotherapy improves event-free, overall, and relapse-free survival, without causing excessive toxicity, according to a phase 3 study published online April 5 in The Lancet.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Esophageal Cancer Surgery Has Lasting Effects on QoL

THURSDAY, April 5 (HealthDay News) -- Long-term survivors of esophageal cancer surgery who experience postoperative complications continue to experience long-lasting adverse effects on their health-related quality of life (HRQL), according to a study published online April 2 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)

Medical Malpractice Claims Incur Substantial Defense Costs

WEDNESDAY, April 4 (HealthDay News) -- Defense costs for medical malpractice claims vary among specialties and are higher for claims that result in indemnity payments, according to a letter published in the April 5 issue of the New England Journal of Medicine.

Full Text

Cancer Diagnosis Linked to Higher Immediate Suicide Risk

WEDNESDAY, April 4 (HealthDay News) -- A recent cancer diagnosis is associated with a higher risk of suicide and death from cardiovascular causes, with the risk being highest in the weeks after diagnosis, according to a study published in the April 5 issue of the New England Journal of Medicine.

Full Text (subscription or payment may be required)

Reduced-Intensity Chemo Effective in Hodgkin's

WEDNESDAY, April 4 (HealthDay News) -- Treating patients with advanced-stage Hodgkin's lymphoma with a reduced-intensity, six-cycle BEACOPPescalated chemotherapy regimen is more effective and less toxic than eight cycles of the same regimen, according to a study published online April 4 in The Lancet.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Metal-on-Metal Bearing Not Linked to Cancer Incidence

WEDNESDAY, April 4 (HealthDay News) -- Hip replacements with metal-on-metal bearing surfaces do not seem to be associated with cancer incidence, according to study published online April 3 in BMJ.

Full Text (subscription or payment may be required)

Childhood Cancer Survivors at Risk for Cardiac Events

WEDNESDAY, April 4 (HealthDay News) -- Childhood cancer survivors (CCSs) treated with anthracyclines and/or cardiac irradiation have a higher risk of developing symptomatic cardiac events (CEs) in the long term, according to a study published online April 2 in the Journal of Clinical Oncology.

Abstract
Full Text (subscription or payment may be required)
Editorial

Mammogram Plus MRI or Ultrasound Catches More Cancer

TUESDAY, April 3 (HealthDay News) -- The addition of an ultrasound or magnetic resonance imaging (MRI) to annual mammography results in a higher rate of detection of incident breast cancers, according to a study published in the April 4 issue of the Journal of the American Medical Association.

Abstract
Full Text (subscription or payment may be required)

Cetuximab With Chemo Doesn't Improve Colon Cancer Outcome

TUESDAY, April 3 (HealthDay News) -- Adding cetuximab to adjuvant chemotherapy does not improve disease-free survival in stage III colon cancer patients following surgical resection, according to a study published in the April 4 issue of the Journal of the American Medical Association.

Abstract
Full Text
Editorial (subscription or payment may be required)

Study Estimates Overdiagnosis From Mammography Screening

TUESDAY, April 3 (HealthDay News) -- Implementation of a mammography screening program leads to a substantial amount of overdiagnosis, according to a study published in the April 3 issue of the Annals of Internal Medicine.

Abstract
Full Text (subscription or payment may be required)

Melanoma Incidence Increasing Among Young Adults

MONDAY, April 2 (HealthDay News) -- From 1970 to 2009, there was an increase in the incidence of melanoma among young adults, particularly females, according to a study published in the April issue of the Mayo Clinic Proceedings.

Abstract
Full Text

Inhibition of Immune Pathway May Trigger Melanoma Growth

MONDAY, April 2 (HealthDay News) -- Melanocyte expression of an immune inhibitory molecule, B7-H1, is associated with the presence of tumor-infiltrating lymphocytes (TILs), according to a study published in the March 28 issue of Science Translational Medicine.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing