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August 2014 Briefing - Hematology & Oncology

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for August 2014. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Report Highlights Progress, Challenges in Health IT

FRIDAY, Aug. 29, 2014 (HealthDay News) -- Progress has been made toward widespread adoption of electronic health records (EHRs), although there are still barriers to adoption of advanced use of EHRs, according to a report published by the Robert Wood Johnson Foundation.

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Photodynamic Therapy Beats Cryotherapy for Actinic Keratoses

FRIDAY, Aug. 29, 2014 (HealthDay News) -- For actinic keratoses (AKs), photodynamic therapy (PDT) is associated with improved response compared with cryotherapy, according to a meta-analysis published online Aug. 27 in JAMA Dermatology.

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Surgery for Spinal Metastasis Up From 2000 to 2009 in U.S.

FRIDAY, Aug. 29, 2014 (HealthDay News) -- From 2000 to 2009 there was an increase in surgical treatment for spinal metastasis in the United States, which was accompanied by increased complication rates and costs, according to a study published in the Sept. 1 issue of The Spine Journal.

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Factors ID'd for Late Hospice Admission for Cancer Patients

FRIDAY, Aug. 29, 2014 (HealthDay News) -- For patients with cancer, factors associated with late admission to hospice have been identified, according to a study published online Aug. 25 in the Journal of Clinical Oncology.

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Poor Prostate Cancer Knowledge Ups Decisional Conflict

FRIDAY, Aug. 29, 2014 (HealthDay News) -- For economically disadvantaged men with newly diagnosed prostate cancer, poor knowledge about prostate cancer is associated with increased decisional conflict and lower perceived effectiveness of decision-making, according to a study published in the Sept. 1 issue of Cancer.

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Worse Outcomes for Weekend Admission for Pediatric Leukemia

FRIDAY, Aug. 29, 2014 (HealthDay News) -- Children with newly diagnosed leukemia with an index admission on the weekend have an increased length of stay and risk for respiratory failure, according to a study published online Aug. 25 in JAMA Pediatrics.

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Doctors Frequently Experience Ethical Dilemmas

THURSDAY, Aug. 28, 2014 (HealthDay News) -- For physicians trying to balance various financial and time pressures, ethical dilemmas are common, according to an article published Aug. 7 in Medical Economics.

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AMGA: Physician Turnover Still High in 2013

THURSDAY, Aug. 28, 2014 (HealthDay News) -- For the second year running, physician turnover remains at the highest rate since 2005, according to a report published by the American Medical Group Association (AMGA).

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Cancer Patients With Depression Often Untreated

THURSDAY, Aug. 28, 2014 (HealthDay News) -- Patients with cancer and depression frequently do not receive effective treatment; however, an integrated program is effective in patients with cancer, and specifically lung cancer, according to three studies published online Aug. 28 in The Lancet Psychiatry, The Lancet, and The Lancet Oncology.

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Guidelines Presented for Diagnosing Focal Liver Lesions

THURSDAY, Aug. 28, 2014 (HealthDay News) -- Focal liver lesions (FLLs) are mostly benign, and can be diagnosed based on knowledge of their presentation, associated clinical and laboratory features, and natural history, according to clinical guidelines published online Aug. 19 in the American Journal of Gastroenterology.

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Molecular Method Classifies Patients With Polycythemia Vera

THURSDAY, Aug. 28, 2014 (HealthDay News) -- Patients with polycythemia vera can be classified according to disease behavior, independently of Janus kinase 2 (JAK2) V617F allele burden, after removing sex as a potential confounder, according to a study published in the Aug. 28 issue of the New England Journal of Medicine.

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Sensory Deficits Common in Patients With Multiple Myeloma

THURSDAY, Aug. 28, 2014 (HealthDay News) -- Treatment-naive patients with multiple myeloma (MM) frequently have sensory deficits, according to a study published online Aug. 25 in the Journal of Clinical Oncology.

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Team Approach Improves Practice Efficiency

WEDNESDAY, Aug. 27, 2014 (HealthDay News) -- The increasing administrative requirements of a medical practice are requiring a team-based approach to care, and physicians must learn to manage the team, according to an article published Aug. 7 in Medical Economics.

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CRC Mortality Down With Removal of Low-Risk Adenomas

WEDNESDAY, Aug. 27, 2014 (HealthDay News) -- For patients who undergo removal of adenomas, colorectal cancer mortality risk is increased for those who had high-risk adenomas removed and reduced for those who had low-risk adenomas removed, according to a study published in the Aug. 28 issue of the New England Journal of Medicine.

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Risk of Diabetes Up in Hodgkin's Lymphoma Survivors

WEDNESDAY, Aug. 27, 2014 (HealthDay News) -- Para-aortic radiation correlates with increased diabetes mellitus (DM) risk for Hodgkin's lymphoma (HL) survivors, according to a study published online Aug. 25 in the Journal of Clinical Oncology.

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Aspirin Post-Anticoagulation Tx Cuts Risk of VTE Recurrence

WEDNESDAY, Aug. 27, 2014 (HealthDay News) -- For patients with first unprovoked venous thromboembolism (VTE), aspirin after anticoagulant treatment reduces the risk of recurrence, according to a study published online Aug. 25 in Circulation.

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Medicaid Office Visit Payment Tied to Cancer Screening Rates

TUESDAY, Aug. 26, 2014 (HealthDay News) -- Increased Medicaid reimbursement for physician office visits is associated with a greater likelihood of Medicaid beneficiaries receiving common cancer screening tests, according to a study published online Aug. 25 in Cancer.

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Vitamin D Deficiency Worsens Outcomes With B-Cell Lymphoma

TUESDAY, Aug. 26, 2014 (HealthDay News) -- Vitamin D deficiency (VDD) contributes to worse outcomes in elderly patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab, according to a study published online Aug. 18 in the Journal of Clinical Oncology.

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Restrictive, Non-Solicitation Covenants Are Valid

MONDAY, Aug. 25, 2014 (HealthDay News) -- Restrictive and non-solicitation covenants are valid and can be enforced, according to an article published Aug. 5 in Medical Economics.

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No Link Found Between Diverticular Disease, Cancer

MONDAY, Aug. 25, 2014 (HealthDay News) -- Colonic diverticular disease does not appear to be linked to an increased risk of subsequent colorectal cancer (CRC), according to research published in the August issue of Clinical Gastroenterology and Hepatology.

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U.S. to Tighten Access to Certain Narcotic Painkillers

FRIDAY, Aug. 22, 2014 (HealthDay News) -- The U.S. Drug Enforcement Administration (DEA) is going ahead with tough new controls on painkillers containing hydrocodone, which has been tied to a surge in dangerous addictions across the United States.

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Organizations Can Help Docs Retain Their Independence

FRIDAY, Aug. 22, 2014 (HealthDay News) -- Ways for physicians to remain in independent practice are highlighted in an article published Aug. 7 in Medical Economics.

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Endogenous Hormones Improve Breast Cancer Risk Models

FRIDAY, Aug. 22, 2014 (HealthDay News) -- Inclusion of endogenous hormones in prediction models improves prediction of invasive breast cancer risk in postmenopausal women, according to a study published online Aug. 18 in the Journal of Clinical Oncology.

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Reduced Nicotine Cigarettes Don't Up Smoking Intensity

FRIDAY, Aug. 22, 2014 (HealthDay News) -- Reduced nicotine cigarettes are not associated with increased smoking intensity versus usual brand cigarettes, according to a study published online Aug. 22 in Cancer Epidemiology, Biomarkers & Prevention.

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Survival Advantage With Surgery in Advanced Laryngeal Cancer

FRIDAY, Aug. 22, 2014 (HealthDay News) -- For patients with advanced laryngeal cancer, there is a small but significant survival advantage with surgical treatment versus laryngeal conservation, according to a study published online Aug. 21 in JAMA Otolaryngology-Head & Neck Surgery.

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CDC: Teens Engage in Unsafe Skin-Protection Practices

THURSDAY, Aug. 21, 2014 (HealthDay News) -- Sunscreen use has decreased among adolescents, and a considerable proportion use indoor tanning devices, according to research published online Aug. 21 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Role of Innervation Explored in Gastric Tumorigenesis

THURSDAY, Aug. 21, 2014 (HealthDay News) -- Vagal innervation is involved in gastric tumorigenesis, according to an experimental study published in the Aug. 20 issue of Science Translational Medicine.

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Clinicopathology of High-Mitotic Rate Melanoma Described

THURSDAY, Aug. 21, 2014 (HealthDay News) -- High-mitotic-rate primary cutaneous melanomas more often occur on the head and neck and in men, older patients, and those with a history of solar keratosis, according to a study published online Aug. 20 in JAMA Dermatology.

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Factors Identified for Reconstruction Post-Mastectomy

WEDNESDAY, Aug. 20, 2014 (HealthDay News) -- More than 40 percent of women undergo breast reconstruction following mastectomy and most patients are satisfied with the reconstruction decision-making process, according to a study published online Aug. 20 in JAMA Surgery.

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FDA Approves Cerdelga for Type 1 Gaucher Disease

WEDNESDAY, Aug. 20, 2014 (HealthDay News) -- Cerdelga (eliglustat) has been approved by the U.S. Food and Drug Administration to treat type 1 Gaucher disease, a rare inherited disorder caused by the body's insufficient production of a key enzyme.

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Organized Processes Help Practices Hire Well

WEDNESDAY, Aug. 20, 2014 (HealthDay News) -- A defined process is necessary to help physicians hire the right staff for their practice, according to an article published July 24 in Medical Economics.

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Active Surveillance Works Well for Stage I Testicular Cancer

WEDNESDAY, Aug. 20, 2014 (HealthDay News) -- Active surveillance for clinical stage I (CSI) testis cancer leads to excellent outcomes, according to a study published online Aug. 18 in the Journal of Clinical Oncology.

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Docs Must Consider Liability When Ordering Screening Tests

TUESDAY, Aug. 19, 2014 (HealthDay News) -- Physicians and health care providers must be aware of their potential liability when ordering screening tests, according to an article published July 24 in Medical Economics.

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Boxed Warnings Are Common in Novel Therapeutics

TUESDAY, Aug. 19, 2014 (HealthDay News) -- Boxed warnings are common on recent drug approvals, and many occur years after approval, according to a research letter published online Aug. 15 in JAMA Internal Medicine.

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Cancer Screening Common in Those With Low Life Expectancy

MONDAY, Aug. 18, 2014 (HealthDay News) -- Cancer screening is common among those with limited life expectancy, and more frequent colorectal cancer screening than recommended does not provide benefit, according to two studies published online Aug. 18 in JAMA Internal Medicine.

Abstract - Royce
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Brisk Walking May Cut Breast Cancer in Black Women

MONDAY, Aug. 18, 2014 (HealthDay News) -- Exercise may be a potentially modifiable risk factor for breast cancer in African-American women, according to a study published online Aug. 7 in Cancer Epidemiology, Biomarkers & Prevention.

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Quadrivalent HPV Vaccine Has Lasting Benefit for Teens

MONDAY, Aug. 18, 2014 (HealthDay News) -- The quadrivalent human papillomavirus (HPV4) vaccine seems safe and effective for adolescents, according to a study published online Aug. 18 in Pediatrics.

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SSRI Meds Up Bleeding Risk in A-Fib Patients Taking Warfarin

MONDAY, Aug. 18, 2014 (HealthDay News) -- In patients with atrial fibrillation taking warfarin, use of selective serotonin reuptake inhibitor (SSRI) medications is associated with an increased risk of major hemorrhage, according to a study published in the Aug. 15 issue of The American Journal of Cardiology.

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Review: Previous Respiratory Conditions Tied to Lung CA Risk

FRIDAY, Aug. 15, 2014 (HealthDay News) -- Several common respiratory diseases are tied to an increased risk of lung cancer, according to a study published online July 23 in the American Journal of Respiratory and Critical Care Medicine.

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FDA Approves Avastin for Late-Stage Cervical Cancer

FRIDAY, Aug. 15, 2014 (HealthDay News) -- The anti-cancer drug Avastin (bevacizumab) has been newly approved to treat aggressive and late-stage cervical cancer, the U.S. Food and Drug Administration said in a news release. The new approval is for use in combination with other anti-cancer drugs, including paclitaxel, cisplatin, and topotecan.

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MRI Better Detects Recurrent Breast Cancer

FRIDAY, Aug. 15, 2014 (HealthDay News) -- Single-screening breast magnetic resonance imaging (MRI) detects 18.1 additional cancers after negative findings with mammography and ultrasonography (US) per 1,000 women with a history of breast cancer, according to a study published in the August issue of Radiology.

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Moderate Exercise Tied to Lower Mortality After Cardiac Event

FRIDAY, Aug. 15, 2014 (HealthDay News) -- Moderate exercise is associated with reduced mortality for heart attack survivors, and elite athletes have lower cardiovascular disease (CVD) and cancer death, according to two studies published online Aug. 12 in the Mayo Clinic Proceedings.

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Direct Bacteria Injections Can Shrink Tumors

THURSDAY, Aug. 14, 2014 (HealthDay News) -- Direct injections of a common bacteria into a tumor can shrink solid tumors, according to a preliminary study published in the Aug. 13 issue of Science Translational Medicine.

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NSAID Use May Cut Breast CA Recurrence in Obese Women

THURSDAY, Aug. 14, 2014 (HealthDay News) -- Daily use of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the recurrence rate of hormone-responsive breast cancer in overweight or obese women, according to research published in the Aug. 15 issue of Cancer Research.

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Extra Time Spent Counseling, Coordinating Care Billable

WEDNESDAY, Aug. 13, 2014 (HealthDay News) -- Extra time spent counseling patients and coordinating care can be billed using evaluation and management (E/M) and prolonged service codes, according to an article published July 24 in Medical Economics.

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Tranexamic Acid Aids Outcomes With Hip, Knee Surgery

WEDNESDAY, Aug. 13, 2014 (HealthDay News) -- The clotting drug tranexamic acid is effective in reducing the need for blood transfusions while not increasing the risk of complications during orthopedic surgery, according to a study published online Aug. 12 in BMJ.

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Once-Only Flexible Sigmoidoscopy Screening Cuts Colorectal Cancer

TUESDAY, Aug. 12, 2014 (HealthDay News) -- Once-only flexible sigmoidoscopy screening, with or without fecal occult blood testing (FOBT), is associated with reduced colorectal cancer incidence and mortality, according to a study published in the Aug. 13 issue of the Journal of the American Medical Association.

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Meta-Analysis Strategy Impacts Estimation of Tx Outcome

TUESDAY, Aug. 12, 2014 (HealthDay News) -- Estimation of treatment outcome varies with the meta-analysis strategy, according to a study published in the Aug. 13 issue of the Journal of the American Medical Association.

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FDA: New Colorectal Cancer Screening Test Approved

TUESDAY, Aug. 12, 2014 (HealthDay News) -- A screening test for colorectal cancer that can detect red blood cells and abnormal DNA in a person's stool has been approved by the U.S. Food and Drug Administration.

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RCTs Show Bisphosphonates Don't Prevent Breast Cancer

TUESDAY, Aug. 12, 2014 (HealthDay News) -- Data from two randomized controlled trials suggest that bisphosphonate use does not protect against postmenopausal breast cancer, according to research published online Aug. 11 in JAMA Internal Medicine.

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Recent Physical Activity Linked to Lower Breast Cancer Risk

TUESDAY, Aug. 12, 2014 (HealthDay News) -- For postmenopausal women, recent recreational physical activity is associated with a lower risk of invasive breast cancer, according to research published online Aug. 11 in Cancer Epidemiology, Biomarkers & Prevention.

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Cancer Care, Outcomes Worse With Medicaid, No Insurance

TUESDAY, Aug. 12, 2014 (HealthDay News) -- Patients with Medicaid insurance or no insurance coverage are less likely to receive cancer-related surgery and/or radiation and are more likely to die from cancer than those with insurance, according to a study published online Aug. 4 in the Journal of Clinical Oncology.

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EHR Adoption Increasing, But Stage 2 Criteria Often Not Met

MONDAY, Aug. 11, 2014 (HealthDay News) -- Most U.S. hospitals and office-based physicians have adopted electronic health records (EHR), according to two studies published in the August issue of Health Affairs.

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Previously Unrecognized Trends in Lung Cancer Identified

MONDAY, Aug. 11, 2014 (HealthDay News) -- An updated and expanded analysis has revealed some new observations about patterns in lung cancer incidence in the United States, according to research published online Aug. 11 in Cancer.

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Issues to Consider With Integration of Telemedicine

FRIDAY, Aug. 8, 2014 (HealthDay News) -- Integrating telemedicine raises various considerations, including operational and legal issues, according to an article published July 24 in Medical Economics.

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Zoster Vaccine Still Effective With Subsequent Chemo

FRIDAY, Aug. 8, 2014 (HealthDay News) -- Zoster vaccine is effective even for individuals who subsequently undergo chemotherapy, according to a study published online Aug. 4 in Clinical Infectious Diseases.

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CDC: Millions Given Access to Breast, Cervical CA Screening

THURSDAY, Aug. 7, 2014 (HealthDay News) -- Millions of American women have benefited from a breast and cervical cancer screening program offered by the U.S. Centers for Disease Control and Prevention, according to a new report. The report was published online and in an Aug. 15 supplement edition of the journal Cancer. The report features 13 new studies evaluating numerous features of the screening program.

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VA Health Care Reform Bill Signed Into Law

THURSDAY, Aug. 7, 2014 (HealthDay News) -- A bill signed into law Thursday by President Barack Obama is meant to provide veterans with easier access to government-paid health care.

Health Highlights: Aug. 7, 2014

Gut Microbiome Analysis Aids Colorectal Cancer Screening

THURSDAY, Aug. 7, 2014 (HealthDay News) -- Analysis of the gut microbiome can better distinguish healthy individuals from those with precancerous adenomatous polyps and those with invasive colorectal cancer, compared to use of traditional clinical risk factors and fecal occult blood testing, according to a study published online Aug. 7 in Cancer Prevention Research.

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Study Confirms Lasting Drop in Prostate Cancer Death With PSA

THURSDAY, Aug. 7, 2014 (HealthDay News) -- Prostate-specific antigen (PSA) screening is associated with a lasting reduction in prostate cancer mortality, with increased effect at 13 years compared with nine or 11 years, according to a study published online Aug. 7 in The Lancet.

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Hospital Risk-Adjusted Margin Positivity Rate Is Quality Metric

THURSDAY, Aug. 7, 2014 (HealthDay News) -- Hospital risk-adjusted margin positivity rate (RAMP) can identify performance-based outliers and represents a rectal cancer surgery quality metric, according to a study published online Aug. 4 in the Journal of Clinical Oncology.

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Many Cancer Survivors Keep Smoking After Diagnosis

WEDNESDAY, Aug. 6, 2014 (HealthDay News) -- Many cancer survivors continue to smoke long after their initial diagnosis, according to research published online Aug. 6 in Cancer Epidemiology, Biomarkers & Prevention.

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Prophylactic Aspirin Use May Help Prevent Cancer

WEDNESDAY, Aug. 6, 2014 (HealthDay News) -- Prophylactic aspirin use seems to be beneficial for men and women between ages 50 and 65 in the general population, with increased benefits seen for long-term use, according to a review published online Aug. 5 in the Annals of Oncology.

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New Mutations Linked to Increased Breast Cancer Risk

WEDNESDAY, Aug. 6, 2014 (HealthDay News) -- Mutations in PALB2 and germline mutations in the multiple endocrine neoplasia type 1 (MEN1) tumor-suppressor gene causing MEN1 correlate with increased breast cancer risk, according to two studies published in the Aug. 7 issue of the New England Journal of Medicine.

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Acupuncture Cuts Comorbid Symptoms of Cancer Pain

WEDNESDAY, Aug. 6, 2014 (HealthDay News) -- Electroacupuncture (EA) may reduce comorbid symptoms of pain in women with breast cancer who have aromatase inhibitor (AI)-related arthralgia, according to research published online July 30 in Cancer.

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Portable Shade Structure Use High for Soccer-Playing Youth

WEDNESDAY, Aug. 6, 2014 (HealthDay News) -- The rate of use of commercially available portable shade structures is high among soccer-playing youths, according to a research letter published online July 30 in JAMA Dermatology.

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Women Over 75 May Still Benefit From Mammograms

TUESDAY, Aug. 5, 2014 (HealthDay News) -- Women 75 and older may still benefit from routine mammograms, according to new research. The study was published online Aug. 5 in Radiology.

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Intrinsic Imaging Phenotypes ID'd for Breast Cancer Tumors

TUESDAY, Aug. 5, 2014 (HealthDay News) -- Intrinsic radiologic phenotypes exist for breast cancer tumors and are associated with prognostic gene expression profiles, according to a study published in the August issue of Radiology.

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Statin Use After CRC Diagnosis Reduces Mortality Risk

TUESDAY, Aug. 5, 2014 (HealthDay News) -- For patients with newly diagnosed colorectal cancer, statin use is associated with reduced cancer-specific mortality risk, according to a study published online Aug. 4 in the Journal of Clinical Oncology.

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Five Servings of Fruit and Veggies a Day Cut Mortality

TUESDAY, Aug. 5, 2014 (HealthDay News) -- Consuming five or more servings of fruit and vegetables daily is associated with reduced risk of all-cause mortality, particularly cardiovascular mortality, according to research published online July 29 in BMJ.

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Many Physicians Have Secondary Income

MONDAY, Aug. 4, 2014 (HealthDay News) -- Many physicians report earning income from sources other than their primary practice/employer, according to an article published July 24 in Medical Economics.

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CMS Recognizes Telehealth in New Physician Fee Schedule

FRIDAY, Aug. 1, 2014 (HealthDay News) -- Earlier this month, the Centers for Medicare & Medicaid Services issued proposed rules for updates to the Physician Fee Schedule and will accept comments until Sept. 2, according to an article published July 7 in Medical Economics.

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Oral Contraceptive, Breast Cancer Link Varies by Formulation

FRIDAY, Aug. 1, 2014 (HealthDay News) -- Recent use of oral contraceptives is associated with increased breast cancer risk, which varies by formulation, according to a study published in the Aug. 1 issue of Cancer Research.

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Healthy Lifestyle Cuts Metabolic Syndrome Risk in CA Survivors

FRIDAY, Aug. 1, 2014 (HealthDay News) -- For childhood cancer survivors, following a heart-healthy lifestyle is associated with a reduced risk of metabolic syndrome (MetS), according to a study published online July 28 in Cancer.

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Each Chronic Condition Further Reduces Life Expectancy

FRIDAY, Aug. 1, 2014 (HealthDay News) -- Each additional chronic condition among older people diminishes life expectancy, according to a study published in the August issue of Medical Care.

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