February 2012 Briefing - Hematology & Oncology

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for February 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Bisphosphonates, Annual BMD Screen Up Fracture Prevention

WEDNESDAY, Feb. 29 (HealthDay News) -- In a hypothetical model of postmenopausal women receiving adjuvant aromatase inhibitors (AIs) for hormone receptor (HR)-positive early breast cancer (EBC), baseline and annual bone mineral density (BMD) screening followed by selective treatment with oral bisphosphonates for those diagnosed with osteoporosis is a cost-effective strategy, according to a study published online Feb. 27 in the Journal of Clinical Oncology.

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Ruxolitinib Reduces Spleen Size in Myelofibrosis

WEDNESDAY, Feb. 29 (HealthDay News) -- For patients with myelofibrosis, treatment with a potent and selective Janus kinase 1 and 2 inhibitor, ruxolitinib, provides significant clinical benefit compared with the best available treatment or placebo, according to two studies published in the March 1 issue of the New England Journal of Medicine.

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Despite Benefits of Selenium, Supplements May Be Harmful

WEDNESDAY, Feb. 29 (HealthDay News) -- While selenium is necessary for good health, levels that are too high can be harmful, and people whose serum selenium levels are already at least 122 µ/L should not take supplements, according to a review published online Feb. 29 in The Lancet.

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Ototoxicity Rates in Children Receiving Carboplatin Studied

WEDNESDAY, Feb. 29 (HealthDay News) -- Retinoblastoma patients who are younger than 6 months of age at the start of carboplatin treatment experience a higher incidence of ototoxicity, according to a study published online Feb. 27 in the Journal of Clinical Oncology.

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Drug Ups Effect of Gemcitabine in Pancreatic Cancer

TUESDAY, Feb. 28 (HealthDay News) -- The efficacy of gemcitabine in treating pancreatic cancer can be greatly improved by a second drug that increases gemcitabine levels by preventing its breakdown, according to a study published online Feb. 28 in Cancer Discovery.

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Dose-Response Link Between Tanning Bed Use, Skin Cancer

TUESDAY, Feb. 28 (HealthDay News) -- Use of tanning beds, especially in high school and college, is associated with an increased risk of skin cancer, according to a study published online Feb. 27 in the Journal of Clinical Oncology.

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Chemo for Breast Cancer Tied to Long-Term Cognitive Issues

MONDAY, Feb. 27 (HealthDay News) -- Women treated with cyclophosphamide, methotrexate, and fluorouracil (CMF) chemotherapy for breast cancer still experience neuropsychological problems decades later, according to a study published online Feb. 27 in the Journal of Clinical Oncology.

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Multimodal Palliative Approach OK for Advanced Esophageal CA

MONDAY, Feb. 27 (HealthDay News) -- For patients with advanced esophageal cancer, use of an individualized, multimodal approach with palliative intention achieves an acceptable mean survival time, with initial use of photodynamic therapy (PDT) offering significantly longer median survival compared to other modalities, according to the results of a single medical center study published online Feb. 14 in Lasers in Surgery and Medicine.

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Ten-Year CML Survival Estimate of 68 Percent With Imatinib

MONDAY, Feb. 27 (HealthDay News) -- For patients with chronic myeloid leukemia that fails to respond to interferon alpha therapy, treatment with imatinib is associated with long-term survival of 68 percent, according to a study published online Feb. 27 in Cancer.

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Older Anesthesiologists Have Higher Litigation Rates

FRIDAY, Feb. 24 (HealthDay News) -- Anesthesiologists over the age of 65 years have a higher frequency of litigation and greater severity of injury than their younger counterparts, according to an article published in the March issue of Anesthesiology.

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Oncogenic HPV Rarely Present in Breast Cancer Tissues

FRIDAY, Feb. 24 (HealthDay News) -- Contrary to numerous reports, oncogenic human papillomavirus (HPV) types are rarely present in mammary epithelium of patients with breast cancer, according to a study published in the March 1 issue of Cancer.

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Expression of Genes for Platelet Aggregation Up Post-CABG

FRIDAY, Feb. 24 (HealthDay News) -- Following coronary artery bypass graft (CABG) surgery, there is increased expression of genes involved in platelet aggregation, including cyclooxygenase-1 (COX1), glycoprotein (GP)IIb and GPIIIa, according to a study published online Feb. 13 in the Journal of Thrombosis and Haemostasis.

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Timeliness of Diagnosis Varies by Cancer and Patient

FRIDAY, Feb. 24 (HealthDay News) -- There is wide variation between cancer types in the proportion of patients who visit their general practitioner three or more times before being referred to the hospital, according to a study published online Feb. 24 in The Lancet Oncology.

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Prevalence of Screening for Lynch Syndrome Varies

THURSDAY, Feb. 23 (HealthDay News) -- Screening for Lynch syndrome, the most common form of inherited colorectal cancer, after a colorectal cancer diagnosis is common at comprehensive cancer centers but not community hospitals, according to a study published online Feb. 21 in the Journal of Clinical Oncology.

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Bisphosphonate Use Linked to Reduced Colorectal Cancer Risk

THURSDAY, Feb. 23 (HealthDay News) -- Exposure to bisphosphonates (BPs) is associated with a reduction in the risk of colorectal cancer (CRC), a reduction that is significant only for risedronic acid, according to a study published in the March 1 issue of Cancer.

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Cancer Risk Up in Bilateral Retinoblastoma Survivors

THURSDAY, Feb. 23 (HealthDay News) -- For survivors of bilateral retinoblastoma (Rb), family history is associated with an increased risk of second cancers (SCs), especially melanoma, according to a study published online Feb. 21 in the Journal of Clinical Oncology.

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Low Neuro-Psych Functioning for Long-Term Glioma Survivors

THURSDAY, Feb. 23 (HealthDay News) -- Long-term survivors of childhood high-grade glioma have intellectual functioning within low-average ranges and low neuropsychological functioning, but the majority of patients report within or above normal quality of life, according to a study published online Feb. 21 in the Journal of Clinical Oncology.

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Defibrotide Prophylaxis Cuts Hepatic Veno-Occlusive Disease

THURSDAY, Feb. 23 (HealthDay News) -- For pediatric patients undergoing hemopoietic stem-cell transplantation (HSCT), defibrotide prophylaxis may reduce the incidence of hepatic veno-occlusive disease, according to the results of a phase 3 open-label randomized controlled study published online Feb. 23 in The Lancet.

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Metastatic Melanoma Responds to Vemurafenib

WEDNESDAY, Feb. 22 (HealthDay News) -- For more than 50 percent of patients with metastatic melanoma with V600 mutations in the serine-threonine protein kinase B-RAF (BRAF V600-mutant metastatic melanoma), treatment with vemurafenib is associated with clinical response, according to a phase 2 trial published in the Feb. 23 issue of the New England Journal of Medicine.

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Mammography-Detected Breast CA Rates Increasing Over Time

WEDNESDAY, Feb. 22 (HealthDay News) -- From 1990 to 2008 there was a significant increase in mammography-detected breast cancer, which coincided with lower-stage disease detection, according to research published in the March issue of Radiology.

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Colonoscopic Removal of Adenomas Cuts CRC Mortality

WEDNESDAY, Feb. 22 (HealthDay News) -- Colonoscopic removal of adenomatous polyps reduces colorectal cancer mortality, and interim analysis shows that fecal immunochemical testing (FIT) yields similar results to colonoscopy; however, more polyps are identified with colonoscopy screening compared to FIT, according to two studies published in the Feb. 23 issue of the New England Journal of Medicine.

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Endometriosis Linked to Higher Ovarian Cancer Risk

WEDNESDAY, Feb. 22 (HealthDay News) -- A history of endometriosis increases the risk of developing ovarian cancer, although the increased risk is restricted to specific subtypes of invasive ovarian cancer, according to a meta-analysis published online Feb. 22 in The Lancet Oncology.

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High VEGF Signaling Score Tied to Lung Cancer Prognosis

WEDNESDAY, Feb. 22 (HealthDay News) -- A high vascular endothelial growth factor (VEGF) signaling score correlates with good prognosis in patients with early squamous cell carcinoma (SCC) of the lung, according to a study published online Feb. 21 in the Journal of Clinical Oncology.

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Skin Cancer Frequency in Chronic Leg Ulcers >10 Percent

WEDNESDAY, Feb. 22 (HealthDay News) -- Chronic leg ulcers (CLUs) that don't heal after three months of appropriate treatment have an overall skin cancer frequency of 10.4 percent, according to a study published online Feb. 20 in the Archives of Dermatology.

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Dermatologist Density Linked to Melanoma Mortality Rates

TUESDAY, Feb. 21 (HealthDay News) -- Melanoma mortality rates are significantly lower in U.S. counties with 0.001 to 2.0 dermatologists per 100,000 people, compared to those with no dermatologist, according to a study published in the February issue of the Archives of Dermatology.

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Normal Breast Protein Linked to Cancer Development

MONDAY, Feb. 20 (HealthDay News) -- Trefoil (TFF3) protein, which maintains the integrity of the epithelial surface in the normal breast, is highly expressed in well-differentiated tumors, correlating with low histological grade, and also has an expression profile which is consistent with a role in breast cancer progression and metastasis, according to a study published in the March issue of The American Journal of Pathology.

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Improved Availability of Sunscreen Increases Usage

FRIDAY, Feb. 17 (HealthDay News) -- Improving college female athletes' access to sunscreen by placing it in golf bags and locker rooms increases its use, according to research published online Feb. 10 in the Journal of the American Academy of Dermatology.

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2002 to 2008 Saw Increase in Partial Nephrectomy Use

FRIDAY, Feb. 17 (HealthDay News) -- In the United States, the use of partial nephrectomy procedures to manage renal masses in patients with renal cell carcinoma (RCC) increased significantly from 2002 to 2008, according to research published in the March issue of The Journal of Urology.

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Thrombopoietic Cytokine Circuit Fuels Ovarian Tumor Growth

THURSDAY, Feb. 16 (HealthDay News) -- In patients with ovarian cancer and in a related mouse model, a paracrine loop involving increased hepatic thrombopoietin and tumor-derived interleukin-6 increases platelet counts and promotes tumor growth, according to a study published in the Feb. 16 issue of the New England Journal of Medicine.

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Age, Nerve Sparing Tied to Post-Prostatectomy Sexual Function

THURSDAY, Feb. 16 (HealthDay News) -- Younger men and those who undergo bilateral nerve sparing (BNS) approaches during a robotic-assisted laparoscopic radical prostatectomy (RALP) have better recovery of their premorbid orgasmic function compared to older men or men with unilateral or non-nerve sparing surgery, according to a study published in the February issue of the BJU International.

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Nutrition Therapy Does Not Improve Cancer Mortality Rate

THURSDAY, Feb. 16 (HealthDay News) -- Nutritional intervention may improve quality of life (QOL) measures in cancer patients with malnutrition, but has no effect on survival rates, according to a study published online Feb. 15 in the Journal of the National Cancer Institute.

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Semuloparin Prophylaxis Effective in Cancer Patients

WEDNESDAY, Feb. 15 (HealthDay News) -- Semuloparin, a hemisynthetic, ultra-low-molecular-weight heparin, reduces the incidence of thromboembolic events in cancer patients receiving chemotherapy, with no increased risk of a major bleeding event, according to a study published in the Feb. 16 issue of the New England Journal of Medicine.

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Behavioral Therapy Safe and Effective for Hot Flashes

WEDNESDAY, Feb. 15 (HealthDay News) -- Women who develop problematic hot flashes after breast cancer treatment, where hormone replacement therapy is contraindicated, see significant improvement in quality of life after receiving behavioral therapy, according to a study published online Feb. 15 in The Lancet Oncology.

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Lynch Syndrome Linked to Increased Risk of Many Cancers

TUESDAY, Feb. 14 (HealthDay News) -- Patients with Lynch syndrome, an inherited disorder of cancer susceptibility caused by mutations in a mismatch repair (MMR) gene, face significantly increased risks of a variety of cancers, including breast and pancreatic cancer, according to a study published online Feb. 13 in the Journal of Clinical Oncology.

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Digital Colposcopy Enhances Cervical Cancer Detection

TUESDAY, Feb. 14 (HealthDay News) -- Dynamic spectral imaging (DSI) colposcopy is more sensitive for detecting cervical intraepithelial neoplasia (CIN2+) in women who are human papillomavirus type 16-positive (HPV16+) than for women who are non-16 high-risk (hr) HPV+, according to a study published online Feb. 3 in BJOG: An International Journal of Obstetrics and Gynaecology.

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New Staging System IDs cSCC Risk in Transplant Patients

TUESDAY, Feb. 14 (HealthDay News) -- The newly updated seventh edition American Joint Committee on Cancer (AJCC) staging system accurately predicts the risk of recurrence of cutaneous squamous cell carcinoma (cSCC) in high-risk heart and lung transplant recipients, according to a study published online Jan. 30 in the Journal of the American Academy of Dermatology.

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Supplements Don't Prevent Cancer in Cardiac Patients

TUESDAY, Feb. 14 (HealthDay News) -- Daily supplementation with B vitamins and/or omega-3 fatty acids is not associated with improved cancer outcomes for survivors of cardiovascular disease, according to a study published online Feb. 13 in the Archives of Internal Medicine.

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Lipid Genetics Linked to Type 2 Diabetes Risk

MONDAY, Feb. 13 (HealthDay News) -- Individuals who are genetically predisposed to have low levels of high-density lipoprotein (HDL) cholesterol or high levels of triglycerides have an increased risk of developing type 2 diabetes, according to a study published online Feb. 7 in Diabetes.

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Radiation Not Tied to Improved Survival in Advanced NSCLC

MONDAY, Feb. 13 (HealthDay News) -- Postoperative radiation therapy (PORT) is not associated with improved survival for elderly patients with N2 non-small-cell lung cancer (NSCLC), according to a study published online Feb. 13 in Cancer.

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Coronary Artery Disease Linked to Risk of Prostate Cancer

MONDAY, Feb. 13 (HealthDay News) -- A significant correlation between coronary artery disease (CAD) and prostate cancer (PCa) has been found among men participating in a prostate drug trial, according to research published online Feb. 7 in Cancer Epidemiology, Biomarkers & Prevention.

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Cancer Risk Higher in Children With Juvenile Arthritis

MONDAY, Feb. 13 (HealthDay News) -- Children with juvenile idiopathic arthritis (JIA) are significantly more likely to develop cancer than children without the condition, although common treatments have no effect on risk, according to a study published online Feb. 10 in Arthritis & Rheumatism.

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Nanotubes and Hyperthermia Kill Breast Cancer Stem Cells in Mice

FRIDAY, Feb. 10 (HealthDay News) -- Injecting carbon nanotubes into breast cancer stem cell-driven tumors followed by hyperthermia with a laser is highly effective in killing these tumors that are normally resistant to conventional hyperthermia, according to a study published in the April issue of Biomaterials.

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Software Helps Resolve Complex DNA Sequence Data

FRIDAY, Feb. 10 (HealthDay News) -- A new software program can help resolve complex DNA sequencing data more quickly and easily than other methods, according to a study published online Feb. 10 in The Journal of Molecular Diagnostics.

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No Long-Term Impairment From Prenatal Exposure to Chemo

FRIDAY, Feb. 10 (HealthDay News) -- General health outcomes and central nervous system, cardiac, and auditory morbidity are not affected by fetal exposure to chemotherapy over the long term, although premature infants exposed to chemotherapy in utero experience impaired cognitive development, according to a study published online Feb. 10 in The Lancet Oncology.

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Radiation Risks From Diagnostic Procedures Examined

THURSDAY, Feb. 9 (HealthDay News) -- National strategies should be developed for the use of evidence-based criteria and improved oversight of equipment to minimize radiation exposure for patients undergoing diagnostic procedures, according to a study published online Feb. 3 in CA: A Cancer Journal for Clinicians.

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Intracerebroventricular Opioid Infusion Feasible at Home

THURSDAY, Feb. 9 (HealthDay News) -- Intracerebroventricular (ICV) infusion of opioids is safe and effective for the treatment of nonresponsive pain in terminally-ill patients in home settings, according to a review published online Feb. 1 in the British Journal of Clinical Pharmacology.

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Guidelines for VTE Prophylaxis in Nonsurgical Patients Issued

THURSDAY, Feb. 9 (HealthDay News) -- New evidence-based clinical practice guidelines have been issued for the prophylaxis of venous thromboembolism (VTE) in nonsurgical patients; the guidelines have been published in a supplement to the February issue of CHEST.

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Acute Myeloid Leukemia Risk Factors ID'd in Texas Adults

THURSDAY, Feb. 9 (HealthDay News) -- Solvent exposure, smoking, and obesity are significant risk factors for de novo acute myeloid leukemia (AML) in Texas, according to a study published online Feb. 1 in Cancer.

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Fasting Augments Chemo in Cancer Cells, Mouse Models

THURSDAY, Feb. 9 (HealthDay News) -- Short cycles of starvation (fasting) sensitizes mammalian cancer cells to chemotherapeutic agents, and may increase the effectiveness of chemotherapy against cancer cells and in mouse models, according to an experimental study published online Feb. 8 in Science Translational Medicine.

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Soy Isoflavones Don't Reduce Breast Epithelial Proliferation

WEDNESDAY, Feb. 8 (HealthDay News) -- Mixed soy isoflavone supplements given over a six-month period show no significant effect in reducing the proliferation of breast cancer epithelial cells in healthy women, according to a study published in the February issue of Cancer Prevention Research.

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Age Affects Risk of Death in Women With Breast Cancer

TUESDAY, Feb. 7 (HealthDay News) -- Among postmenopausal women with hormone receptor-positive breast cancer, increasing age is associated with a higher risk of death from breast cancer, according to a study published in the Feb. 8 issue of the Journal of the American Medical Association.

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Breast Cancer Prevention Drug Linked to Bone Loss

TUESDAY, Feb. 7 (HealthDay News) -- Postmenopausal women receiving the aromatase inhibitor exemestane to prevent breast cancer are more likely to have bone loss, according to a study published online Feb. 7 in The Lancet Oncology.

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Patients Desire Involvement in Planning Breast CA Treatment

TUESDAY, Feb. 7 (HealthDay News) -- Many patients with early-stage breast cancer have a desire for decisional control, which increases postconsultation, and patients who are involved in decisions have better decision-related outcomes, according to a study published online Feb. 6 in the Journal of Clinical Oncology.

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Three 'Targeted' Cancer Drugs Up Risk of Fatal Adverse Events

TUESDAY, Feb. 7 (HealthDay News) -- The use of vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) to treat cancer is associated with an increased risk of fatal adverse events (FAEs) but there is no difference in rates of FAEs between the different VEGFR TKIs or tumor types, according to a meta-analysis published online Feb. 6 in the Journal of Clinical Oncology.

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Pediatric Stem Cell Transplant Recipients Are Resilient

MONDAY, Feb. 6 (HealthDay News) -- Pediatric patients undergoing stem cell transplantation (SCT) have a positive overall adjustment and health-related quality of life (HRQL), according to a study published online Feb. 6 in Pediatrics.

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Increased ADHD Rates in Children Exposed to Anesthesia

FRIDAY, Feb. 3 (HealthDay News) -- Repeated exposure to general anesthesia before age 2 years is associated with increased risk for later development of attention-deficit/hyperactivity disorder (ADHD), according to a study published in the February issue of Mayo Clinic Proceedings.

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Prostate Size Predicts Gleason Score Upgrading

FRIDAY, Feb. 3 (HealthDay News) -- For men with low-risk prostate cancer, prostate size is an independent predictor of Gleason score upgrading, according to a study published in the December issue of The Journal of Urology.

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High Alcohol Intake, Family History Impact Colon CA Risk

FRIDAY, Feb. 3 (HealthDay News) -- Individuals who consume 30 g alcohol or more per day have a significantly elevated risk of colon cancer, especially those with a family history of colorectal cancer, according to a study published in the February issue of the American Journal of Clinical Nutrition.

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Smoking Increases Progression Risk in Barrett's Esophagus

FRIDAY, Feb. 3 (HealthDay News) -- Patients with Barrett's esophagus who currently smoke have twice the risk of developing esophageal cancer compared with never smokers, according to a study published in the February issue of Gastroenterology.

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Ghrelin Stimulates Food Intake During Cisplatin-Based Chemo

THURSDAY, Feb. 2 (HealthDay News) -- Administration of synthetic ghrelin during chemotherapy improves food intake and appetite in patients with esophageal cancer, while minimizing gastrointestinal disorders, according to a study published online Jan. 26 in Cancer.

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Gleevec Approval Widened to Include Rare Cancer

WEDNESDAY, Feb. 1 (HealthDay News) -- U.S. Food and Drug Administration approval for the Novartis drug Gleevec has been expanded to include adults who have had surgical removal of CD117-positive gastrointestinal stromal tumors (GIST), the agency said in a news release.

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Exercise Aids Health, Well-Being of Cancer Survivors

WEDNESDAY, Feb. 1 (HealthDay News) -- Exercise is associated with improvements in physical functions and quality of life in patients who have completed cancer treatment, according to a meta-analysis published online Jan. 31 in BMJ.

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Repeat Flexible Sigmoidoscopy Increases Detection of CRC

WEDNESDAY, Feb. 1 (HealthDay News) -- Repeated screening by flexible sigmoidoscopy (FSG) increases the detection of colorectal cancer or advanced adenoma in women and men, according to a study published online Jan. 31 in the Journal of the National Cancer Institute.

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