Here are what the editors at HealthDay consider to be the most important developments in Oncology for October 2009. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Endorectal Imaging Benefit Seen in Prostate Cancer
FRIDAY, Oct. 30 (HealthDay News) -- Endorectal magnetic resonance (MR) imaging may be useful in categorizing men with stage T1c prostate cancer for proper treatment management, according to research published in the November issue of Radiology.
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Benefits Seen From Concurrent Chemotherapy and Radiation
FRIDAY, Oct. 30 (HealthDay News) -- In patients with locally advanced head and neck cancer who hadn't undergone surgery, concurrent radiotherapy and non-platinum chemotherapy was associated with fewer recurrences and deaths over 10 years, according to research published online Oct. 28 in The Lancet Oncology.
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Proteins Expressed in Liver Cancer May Indicate Prognosis
FRIDAY, Oct. 30 (HealthDay News) -- The expression of certain epithelial-mesenchymal transition (EMT) protein regulators in primary hepatocellular carcinoma (HCC) are correlated with disease invasiveness, metastasis and a poor prognosis, according to a study in the November issue of Hepatology.
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Study Finds Benefits With Full-Field Digital Mammography
THURSDAY, Oct. 29 (HealthDay News) -- Full-field digital mammography (FFDM), along with computer-aided diagnosis (CAD), may provide improved detection of microcalcifications and ductal carcinoma in situ, according to research published in the November issue of Radiology.
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Additional Recommendations for Imaging on the Rise
THURSDAY, Oct. 29 (HealthDay News) -- Recommendations for additional imaging in radiology reports at one institution increased steeply in recent years, and from 1980 to 2006, radiologic and nuclear medicine procedures increased roughly 10-fold and 2.5 fold, respectively, according to two studies the November issue of Radiology.
Abstract - Sistrom
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Gene Alterations Replicate Neurofibromatosis in Mice
THURSDAY, Oct. 29 (HealthDay News) -- Mice containing alterations in two genes involved in cellular signaling are a good model for neurofibromatosis (NF) and its transformation into malignant sarcomas, according to a study published online Oct. 21 in the Proceedings of the National Academy of Sciences.
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Vessel Type Linked to Disease Severity in Prostate Cancer
THURSDAY, Oct. 29 (HealthDay News) -- Men with prostate tumors whose vascular supply consists of vessels with primitive morphology are more likely to develop lethal disease, according to a study published online Oct. 26 in the Journal of Clinical Oncology.
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Prostate-Specific Antigen Velocity Linked to Mortality
THURSDAY, Oct. 29 (HealthDay News) -- Men with unfavorable prostate cancer whose prostate-specific antigen (PSA) levels rapidly increase at recurrence have a higher risk of death, but only if they have no or minimal comorbidities, according to a study published online Oct. 26 in the Journal of Clinical Oncology.
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Overweight Patients May Have Effect on Doctor's Attitude
THURSDAY, Oct. 29 (HealthDay News) -- Physicians have lower respect for patients with high body mass index (BMI), which may have an impact on patient care and outcomes, according to a study published online Sept. 18 in the Journal of General Internal Medicine.
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Racial Disparities Found in Breast Cancer Screening
WEDNESDAY, Oct. 28 (HealthDay News) -- In a statewide screening program for low-income women in South Carolina, race appeared to affect the time to completion of diagnostic workup following suspicious breast abnormalities, according to research published online Oct. 26 in Cancer.
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Radiologists May Be Reluctant to Disclose Mammography Errors
WEDNESDAY, Oct. 28 (HealthDay News) -- Few radiologists say they would definitely disclose an error affecting the diagnosis of a patient with breast cancer, according to a study in the Oct. 28 issue of Radiology.
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Contralateral Breast Cancer Risk High With Gene Mutation
WEDNESDAY, Oct. 28 (HealthDay News) -- Women with cancer in one breast who come from families with a hereditary breast cancer mutation have a nearly 50 percent long-term risk of developing cancer in the opposite breast, particularly if they are younger at first diagnosis, according to a study published online Oct. 26 in the Journal of Clinical Oncology.
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Testicular Cancer Survivors Report High Quality of Life
WEDNESDAY, Oct. 28 (HealthDay News) -- Long-term survivors of testicular cancer generally report a high quality of life, according to a study published online Oct. 26 in the Journal of Clinical Oncology.
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FDA: Arzerra Approved for Chronic Lymphocytic Leukemia
TUESDAY, Oct. 27 (HealthDay News) -- Arzerra (ofatumumab) has been approved by the U.S. Food and Drug Administration to treat chronic lymphocytic leukemia (CLL), a cancer of the blood and bone marrow.
approval history
Medical School Enrollment Continues to Expand
MONDAY, Oct. 26 (HealthDay News) -- Almost 18,400 students enrolled in medical school in the United States in 2009, a 2 percent increase over the previous year, but even more expansion is needed to meet future demand, according to an Oct. 20 report from the Association of American Medical Colleges (AAMC).
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Protein Linked to Development of Some Lung Cancers
MONDAY, Oct. 26 (HealthDay News) -- Lung cancers with alterations in two genes may be susceptible to inhibitors that target a protein important in cellular processes such as inflammation and fighting infection, according to an animal study published online Oct. 21 in Nature.
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Low-Dose Regimen Found to Improve Myeloma Survival
MONDAY, Oct. 26 (HealthDay News) -- Lenalidomide plus low-dose dexamethasone is associated with better survival than lenalidomide plus high-dose dexamethasone for treating newly diagnosed multiple myeloma, according to a study published online Oct. 22 in The Lancet Oncology.
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Researchers Evaluate New Prostate Specific Antigen Test
FRIDAY, Oct. 23 (HealthDay News) -- A new test for prostate-specific antigen (PSA) levels is considerably more sensitive than commercial assays and allows better monitoring for recurrence after prostatectomy for early-stage prostate cancer, according to a study published online Oct. 19 in the Proceedings of the National Academy of Sciences.
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Childhood-Cancer Survivors at Risk of Suicidal Thoughts
FRIDAY, Oct. 23 (HealthDay News) -- Adult survivors of childhood cancers are more likely to have thoughts of suicide, particularly if they are in poor mental and physical health, according to a study published online Oct. 19 in the Journal of Clinical Oncology.
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Neonatal Outcomes Examined in Cancer Pregnancies
FRIDAY, Oct. 23 (HealthDay News) -- Pregnancies in women with cancer tend to have good outcomes overall, but have been associated with high rates of induced labor and newborn admission to a neonatal intensive care unit (NICU), according to a study published online Oct. 19 in the Journal of Clinical Oncology.
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Radiation for Prostate Linked to Later Pelvic Cancer
THURSDAY, Oct. 22 (HealthDay News) -- Radiation following radical surgery for prostate cancer may increase the risk of late primary pelvic second primary cancer, according to research published in the October issue of Urology.
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Some Hospital Staff Predicted to Be Infection Superspreaders
THURSDAY, Oct. 22 (HealthDay News) -- Hospital staff such as therapists and radiologists who are in contact with all patients have the potential to be superspreaders of infection if they fail to wash their hands regularly, according to a study published online Oct. 19 in the Proceedings of the National Academy of Sciences.
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Benefit of BRCA Testing in Ovarian Cancer Examined
THURSDAY, Oct. 22 (HealthDay News) -- Testing women with ovarian cancer for the BRCA mutation if they have a personal history of breast cancer, a family history of breast or ovarian cancer, or are of Ashkenazi Jewish ancestry, is a cost-effective strategy that may prevent cancers in first degree relatives (FDR), according to a study published online Oct. 19 in the Journal of Clinical Oncology.
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Cisplatin Alone Effective in Children With Hepatoblastoma
WEDNESDAY, Oct. 21 (HealthDay News) -- Cisplatin alone is just as effective as, but less toxic than, cisplatin plus doxorubicin in children with standard-risk hepatoblastoma, according to a study in the Oct. 22 issue of the New England Journal of Medicine.
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Most H1N1 Hospitalizations Are in Young Patients
WEDNESDAY, Oct. 21 (HealthDay News) -- More than half of hospitalizations for H1N1 influenza are occurring in people younger than 25 years of age, and very few are occurring in the elderly, according to information presented at the Oct. 20 press briefing by the U.S. Centers for Disease Control and Prevention.
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Clinical Approach for Invasive Fungal Disease Explored
WEDNESDAY, Oct. 21 (HealthDay News) -- A clinically driven approach to neutropenia-induced invasive fungal disease (IFD) can expedite diagnosis and reduce unnecessary antifungal treatment compared to standard empirical and preemptive strategies, according to a study published online Oct. 19 in the Journal of Clinical Oncology.
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Sources Find Different Numbers of Active Physicians
WEDNESDAY, Oct. 21 (HealthDay News) -- Estimates from U.S. Census Bureau surveys find fewer older physicians remaining active compared with the American Medical Association Physician Masterfile data, according to research published in the Oct. 21 issue of the Journal of the American Medical Association.
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Drugs to Treat Bowel Disease Linked to Lymphomas
MONDAY, Oct. 19 (HealthDay News) -- Thiopurine drugs given as immunosuppressants to treat inflammatory bowel disease are associated with a more than five-fold risk of developing lymphomas, according to a study published online Oct. 19 in The Lancet.
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FDA Approves Vaccines for HPV-Related Disease
MONDAY, Oct. 19 (HealthDay News) -- On Oct. 16, the U.S. Food and Drug Administration approved two vaccines to prevent diseases related to human papillomavirus (HPV) in males and females.
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Study Assesses Testicular Cancer Survivors' Symptoms
MONDAY, Oct. 19 (HealthDay News) -- Among survivors of testicular cancer, clinical symptoms of androgen deficiency were linked to sexual problems and older age, but not serum testosterone, according to research published in the October issue of Urology.
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Partner's Education Linked to Death Risk of Both in Couple
FRIDAY, Oct. 16 (HealthDay News) -- Among married or cohabiting couples, women's education and men's social class appear to have an important effect on the mortality risk of both partners, according to research published online Oct. 6 in the Journal of Epidemiology and Community Health.
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FDA Launches Drug Disposal Advice Web Page
FRIDAY, Oct. 16 (HealthDay News) -- The U.S. Food and Drug Administration has launched a new Web page for consumers to educate them on the safe disposal of certain medicines that can be dangerous or even fatal if they end up in the wrong hands.
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Oncologists May Often Fail to Refer for Fertility Counseling
FRIDAY, Oct. 16 (HealthDay News) -- Less than half of U.S. oncologists refer their cancer patients of childbearing age for counseling on fertility preservation, according to a study published online Oct. 13 in the Journal of Clinical Oncology.
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Prediction Model Can Benefit Bladder Cancer Patients
THURSDAY, Oct. 15 (HealthDay News) -- In the management of bladder cancer patients who have undergone cystectomy, use of a multivariate prediction model ("bladder nomogram") for referral to adjuvant chemotherapy may lead to better outcomes than the use of pathologic stage, according to a study published online Oct. 12 in Cancer.
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Study Links Text Messages and E-mails to Smoking Cessation
THURSDAY, Oct. 15 (HealthDay News) -- While short-term text message mobile phone interventions have been effective, further research needs to be completed to determine whether messages sent over mobile phones can help individuals with smoking cessation over the long term, according to research published online Oct. 7 in the Cochrane Database of Systematic Reviews.
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Physician Detailing Improves Colonoscopy Screening Rates
WEDNESDAY, Oct. 14 (HealthDay News) -- A series of detailing sessions to small urban physician practices about colorectal cancer (CRC) screening improved the practices' screening rates by 7 percent, but not cost-effectively, according to a study published online Oct. 13 in the Journal of Clinical Oncology.
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Exercise Can Decrease Fatigue in Chemotherapy Patients
WEDNESDAY, Oct. 14 (HealthDay News) -- In cancer patients who are undergoing chemotherapy, a multi-modal exercise program may significantly reduce fatigue, according to a study published online Oct. 13 in BMJ.
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Acceptance of Prognosis Can Help Cancer Patients Cope
WEDNESDAY, Oct. 14 (HealthDay News) -- Patients with advanced cancer are more likely to be depressed and anxious if they have not come to terms with their situation, according to a study published online Oct. 13 in the Journal of Clinical Oncology.
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Possible Link Found Between Tumors and Mobile Phone Use
WEDNESDAY, Oct. 14 (HealthDay News) -- There is a possible link between mobile phone use and higher risk of tumors, but studies with a higher level of evidence are needed for confirmation, according to a study published online Oct. 13 in the Journal of Clinical Oncology.
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Mixed Outcomes Seen for Less Invasive Prostate Surgery
TUESDAY, Oct. 13 (HealthDay News) -- Although minimally invasive radical prostatectomy (MIRP) may be associated with some benefits compared to retropubic radical prostatectomy (RRP), it is also associated with more genitourinary complications, according to research published in the Oct. 14 issue of the Journal of the American Medical Association.
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Breast-Conserving Surgery, Mastectomy Rates Surveyed
TUESDAY, Oct. 13 (HealthDay News) -- Breast-conserving surgery (BCS) is attempted in the majority of patients, with factors linked to mastectomy including surgeon recommendation, personal decision and failure of BCS, according to results of a survey published in the Oct. 14 issue of the Journal of the American Medical Association.
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Standards of Care Evolving for Uncommon Uterine Cancer
TUESDAY, Oct. 13 (HealthDay News) -- Uterine papillary serous carcinoma (UPSC), the less common form of endometrial cancer, causes a disproportionate number of deaths, and more clinical trials are needed to develop evidence-based management strategies, according to a literature review in the October issue of Gynecologic Oncology.
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Study Evaluates Hospital Quality and Mortality Rates
TUESDAY, Oct. 13 (HealthDay News) -- Hospital mortality rates in the United States have improved, although major differences in quality still exist between the best and worst hospitals, according to a report published Oct. 13 by HealthGrades.
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Risk of Cancers in HIV-Infected Patients Assessed
MONDAY, Oct. 12 (HealthDay News) -- Immunodeficiency greatly increases the risk of seven AIDS-defining and non-AIDS-defining cancers in HIV-infected patients, and combination treatment that increases CD4 counts can reduce this risk, according to a study published online Oct. 8 in The Lancet Oncology.
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Health Care Disparities Among States Found to Be Widening
FRIDAY, Oct. 9 (HealthDay News) -- Increasing health care costs and growing disparities in coverage among U.S. states point to the urgent need for national health care reform, according to an Oct. 8 state-by-state report card from the Commonwealth Fund Commission, a private foundation supporting research on the health care system.
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Study Assesses Survival After Second Primary Neoplasms
FRIDAY, Oct. 9 (HealthDay News) -- In survivors of childhood cancer, survival following second primary glioma is poor, though the outlook is good for second primary meningioma, according to research published online Sept. 28 in the Journal of Clinical Oncology.
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Cancer Survivorship Has Little Effect on Birth Outcomes
FRIDAY, Oct. 9 (HealthDay News) -- Most infants born to female and male survivors of childhood and adolescent cancer are not at increased risk of overall complications, but may be at increased risk of preterm delivery or low birth weight, according to two studies published in the October issue of the Archives of Pediatrics & Adolescent Medicine.
Abstract - Mueller
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Abstract - Chow
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Cancer Patients at Risk of Jaw Necrosis After Treatment
THURSDAY, Oct. 8 (HealthDay News) -- Cancer patients treated with bisphosphonates have a higher risk of developing osteonecrosis of the jaw (ONJ) if they have had dental extractions or dentures, according to a study published online Oct. 5 in the Journal of Clinical Oncology.
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Seasonal Flu Vaccine Protects Somewhat Against A/H1N1
THURSDAY, Oct. 8 (HealthDay News) -- There are early signs that the 2008/2009 trivalent inactivated seasonal flu vaccination offers some protection against influenza A/H1N1, particularly in its most severe forms, but this should not be taken to mean that vaccination against swine flu is superfluous, according to a study published online Oct. 6 in BMJ.
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Roundtable Discussion Tackles Health Care Reform
WEDNESDAY, Oct. 7 (HealthDay News) -- The health care payment system, the role of consumers in responsible health care spending, and the use of comparative-effectiveness research were topics covered in a roundtable discussion with several health economics experts published in the Oct. 8 issue of the New England Journal of Medicine.
Roundtable
Perspective - Cutler
MicroRNA Biomarker Linked to Survival in Liver Cancer
WEDNESDAY, Oct. 7 (HealthDay News) -- A microRNA biomarker has been identified in liver tumors, with differing levels by gender, and associated with survival and response to interferon treatment, according to a study in the Oct. 8 issue of the New England Journal of Medicine.
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Medical Students Want More Practice of Medicine Training
WEDNESDAY, Oct. 7 (HealthDay News) -- Medical students in the United States perceive that they are not getting enough training in the practice of medicine, particularly in medical economics, according to a study in the September issue of Academic Medicine.
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Glioma Risk Associated With Youth Obesity and Inactivity
WEDNESDAY, Oct. 7 (HealthDay News) -- The risk of glioma is greater among those who are tall and those who were inactive or obese in adolescence, suggesting a link between the cancer and early-life energy balance, according to a study published online Oct. 6 in Cancer Research.
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Technique May Aid Detection of Residual Leukemia
WEDNESDAY, Oct. 7 (HealthDay News) -- A technique that tags leukemia cells using antibody-coated magnetic nanoparticles and allows them to be preferentially sampled greatly increases the ability to detect residual disease, according to a study published online Oct. 6 in Cancer Research.
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Effectiveness and Cost Help to Make Coverage Decisions
TUESDAY, Oct. 6 (HealthDay News) -- Countries using evidence-based cost-effectiveness and effectiveness to help make drug coverage decisions show how these factors can successfully support decision making and can also be adapted to the specific conditions of other countries, according to a study in the Oct. 7 issue of the Journal of the American Medical Association.
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CYP2D6 Variants Linked With Tamoxifen Response
TUESDAY, Oct. 6 (HealthDay News) -- In patients with early-stage breast cancer undergoing adjuvant tamoxifen treatment, an association may exist between the polymorphic cytochrome P450 2D6 (CYP2D6) enzyme and clinical outcomes, according to a retrospective analysis published in the Oct. 7 issue of the Journal of the American Medical Association.
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Novel Features of Breast Tissue May Predict Cancer Risk
TUESDAY, Oct. 6 (HealthDay News) -- Assessing the features of a woman's normal breast tissue can help to identify those at increased risk of breast cancer, according to a study published online Oct. 5 in the Journal of Clinical Oncology.
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Non-Cardiac Incidental Results Rarely Clinically Significant
TUESDAY, Oct. 6 (HealthDay News) -- Non-cardiac findings found by cardiac computed tomography (CT) are usually not clinically significant and have no impact on death rates, but can lead to complications and add to health care costs, according to a study in the Oct. 13 Journal of the American College of Cardiology.
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Augmentation of Antiemetic Drug Regimen Explored
TUESDAY, Oct. 6 (HealthDay News) -- The addition of casopitant, a neurokinin (NK)-1 receptor antagonist, to an antiemetic regimen of dexamethasone and ondansetron reduced vomiting and use of rescue medications in breast cancer patients undergoing their first cycle of chemotherapy, according to a study published online Oct. 5 in the Journal of Clinical Oncology.
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Latinas Found Less Likely to Receive Breast Reconstruction
TUESDAY, Oct. 6 (HealthDay News) -- Less acculturated Latinas with breast cancer are less likely to receive breast reconstruction than Caucasian women but are most likely to want more information about it, and underweight Korean breast cancer patients are at higher risk of death and breast cancer recurrence, according to two studies published online Oct. 5 in the Journal of Clinical Oncology.
Abstract - Alderman
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Abstract - Moon
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Nicotine Replacement in Pregnant Smokers Likely Safe
MONDAY, Oct. 5 (HealthDay News) -- Nicotine replacement therapy does not increase the risk of adverse events in pregnant smokers, according to a study in the October issue of the American Journal of Obstetrics & Gynecology.
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Combination May Improve Prostate Cancer Prediction
MONDAY, Oct. 5 (HealthDay News) -- Combining endorectal MRI, magnetic
resonance spectroscopy, and a low free-to-total prostate-specific antigen (PSA) ratio is highly accurate in predicting prostate cancer in men with high PSA levels, according to a European study in the October issue of Radiology.
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Procedure May Be Helpful in Diagnosing Prostate Cancer
FRIDAY, Oct. 2 (HealthDay News) -- Transurethral prostate resection may be a useful addition to prostate biopsy in detecting cancer in men whose prostate-specific antigen (PSA) remains a concern after previous negative biopsies, according to research published in the October issue of the Journal of Urology.
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Rising Numbers of Elderly Will Pose Issues for Nations
FRIDAY, Oct. 2 (HealthDay News) -- An anticipated rise in life expectancy, involving more than half of babies born in wealthy nations living to 100, will cause societal and economic challenges in coming decades, according to research published in the Oct. 3 issue of The Lancet.
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Low Late Toxicity With Radiation Post Prostatectomy
THURSDAY, Oct. 1 (HealthDay News) -- Men with prostate cancer who receive salvage external beam radiotherapy (EBRT) after radical prostatectomy have a low risk of severe late toxicity, according to a study published online Sept. 22 in Radiotherapy & Oncology.
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Surgical Masks Found to Be Non-Inferior to Respirators
THURSDAY, Oct. 1 (HealthDay News) -- Surgical masks may be no less effective than N95 respirators in preventing influenza in health care workers, according to a study published online Oct. 1 in the Journal of the American Medical Association.
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CDC Says States Not Meeting Fruit and Veggie Objectives
THURSDAY, Oct. 1 (HealthDay News) -- In a Sept. 29 press release, the U.S. Centers for Disease Control and Prevention says no U.S. state is currently meeting the national Healthy People 2010 objectives for fruit and vegetable consumption.
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Physicians May Fail to Act on Electronic Alerts Quickly
THURSDAY, Oct. 1 (HealthDay News) -- Physicians using a system with electronic medical records and computerized alerts may not acknowledge or act upon critical imaging results in a timely manner, according to research published in the Sept. 28 Archives of Internal Medicine.
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