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September 2014 Briefing - Hematology & Oncology

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for September 2014. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Low Professional Liability for No Esophageal Cancer Screening

TUESDAY, Sept. 30, 2014 (HealthDay News) -- The risk of medical professional liability claims alleging failure to screen for esophageal cancer is not a reason to screen for esophageal cancer, according to a research letter published in the Oct. 1 issue of the Journal of the American Medical Association.

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'Just-in-Time' Methodology Can Reduce Patient Waiting Times

MONDAY, Sept. 29, 2014 (HealthDay News) -- Having trainee physicians review cases prior to clinic hours can reduce patient waiting times, flow times, and clinic session times, according to a study published online Sept. 16 in Pain Medicine. The management process studied was first popularized by Toyota in Japan.

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AMA Launches Three Programs for Physician Wellness

MONDAY, Sept. 29, 2014 (HealthDay News) -- Physicians' personal health is a global concern and three initiatives are being developed to encourage positive change, according to a report from the American Medical Association (AMA).

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Experiences Trump Things, Even Before Purchase

FRIDAY, Sept. 26, 2014 (HealthDay News) -- People derive value from the anticipation of purchasing something, and this anticipation tends to be greater for an experiential purchase than for a material purchase, according to a study published online Aug. 21 in Psychological Science.

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Routine Post-Op Labs Don't Often Affect Cervical Discectomy Care

FRIDAY, Sept. 26, 2014 (HealthDay News) -- In most cases, no action is taken on the basis of patient's routine postoperative laboratory data after anterior cervical discectomy and fusion (ACDF), according to a study published in the Sept. 15 issue of Spine.

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Higher HDL Cholesterol May Help Protect Against Cancer

FRIDAY, Sept. 26, 2014 (HealthDay News) -- Higher levels of high-density lipoprotein cholesterol (HDL-C) are associated with a decreased risk of cancer among individuals with type 2 diabetes, according to a study published online Sept. 11 in Diabetes Care.

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Can Media Multitasking Alter Your Brain?

THURSDAY, Sept. 25, 2014 (HealthDay News) -- Multitasking with smartphones, laptop computers, and other media devices could change the structure of your brain, according to a study published online Sept. 24 in PLOS ONE.

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Increasing Skirt Size Tied to Higher Breast Cancer Risk

THURSDAY, Sept. 25, 2014 (HealthDay News) -- For each increase in skirt size every 10 years, the risk of developing breast cancer after menopause could increase by 33 percent, according to research published online Sept. 24 in BMJ Open.

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Lung Infections May Hamper Ability to Detect Lung Cancer

WEDNESDAY, Sept. 24, 2014 (HealthDay News) -- A test used to diagnose lung cancer may not be as reliable in geographic regions where certain lung infections are more common, according to research published in the Sept. 24 issue of the Journal of the American Medical Association.

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Most Doctors Are Over-Extended or at Full Capacity

WEDNESDAY, Sept. 24, 2014 (HealthDay News) -- Most physicians report being over-extended or at full capacity, according to a survey conducted by Merritt Hawkins for The Physicians Foundation.

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Gut Microbiome Diversity Linked to Endogenous Estrogens

WEDNESDAY, Sept. 24, 2014 (HealthDay News) -- Diversity of fecal microbiome is associated with an increased ratio of hydroxylated estrogen metabolites to parent estrogen, according to a study published online Sept. 11 in the Journal of Clinical Endocrinology and Metabolism.

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Report Identifies Game Changers for U.S. Health Care

WEDNESDAY, Sept. 24, 2014 (HealthDay News) -- Imagine if doctors and hospitals got paid for providing better care, not more care, and patients had better data for making informed health choices. A new report suggests that's the direction the U.S. health system is headed.

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FDA Warns Doctors of Danger From 'Fake' Drugs

TUESDAY, Sept. 23, 2014 (HealthDay News) -- The number of "rogue" wholesale distributors selling fake or unapproved prescription drugs is growing, so doctors need to be vigilant when purchasing medicines, the U.S. Food and Drug Administration warned Tuesday.

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FDA: Blood Test for Yeast Pathogens Approved

TUESDAY, Sept. 23, 2014 (HealthDay News) -- The first blood test to detect five yeast pathogens that can cause blood infections in people with weakened immune systems has been approved by the U.S. Food and Drug Administration. The five yeast pathogens are Candida albicans and/or Candida tropicalis, Candida parapsilosis, Candida glabrata and/or Candida krusei.

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Generic Discount Drug Program Use Has Increased Over Time

TUESDAY, Sept. 23, 2014 (HealthDay News) -- Use of the generic discount drug program (GDDP) for filling prescriptions with generic drugs has increased since its introduction, according to a research letter published online Sept 22 in JAMA Internal Medicine.

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NIH Adds $10M to Encourage Gender Balance in Clinical Trials

TUESDAY, Sept. 23, 2014 (HealthDay News) -- The U.S. National Institutes of Health is investing $10 million in additional funding in scientific trials to encourage researchers to consider gender in their preclinical and clinical studies.

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E-Cigarettes Don't Help Cancer Patients Quit Smoking

MONDAY, Sept. 22, 2014 (HealthDay News) -- Smokers with cancer who used e-cigarettes along with traditional cigarettes were more dependent on nicotine than those who didn't use the devices, a Memorial Sloan Kettering study found. These patients were also just as likely -- or less likely -- to have quit smoking than patients who didn't use e-cigarettes.

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Pancreatic Cancer Risk Not Higher With Diabetes Rx DPP-4i

MONDAY, Sept. 22, 2014 (HealthDay News) -- There is no increased short-term pancreatic cancer risk with dipeptidyl-peptidase-4 inhibitors (DPP-4i) compared to sulfonylureas (SU) and thiazolidinediones (TZD) for glycemic control, according to a study published online Sept. 10 in Diabetes, Obesity and Metabolism.

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Systemwide Changes Needed to Restrain Health Care Spending

FRIDAY, Sept. 19, 2014 (HealthDay News) -- Systemwide changes are necessary to prevent excessive health care spending, and so are tools to help consumers make better, more informed medical choices, according to a white paper published in June by Vitals.

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Breast Cancer Subtype Affects Survival With Spinal Metastasis

FRIDAY, Sept. 19, 2014 (HealthDay News) -- For patients with breast cancer with spinal metastases, estrogen receptor (ER)/hormone receptor (HR)-negative status is associated with worse survival, according to a study published in the Sept. 1 issue of Spine.

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Presence of Peers Ups Health Workers' Hand Hygiene

FRIDAY, Sept. 19, 2014 (HealthDay News) -- The presence of other health care workers improves hand hygiene adherence, according to a study published in the October issue of Infection Control and Hospital Epidemiology.

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Family Squabbles Can Derail Recovery From Cancer Surgery

FRIDAY, Sept. 19, 2014 (HealthDay News) -- Cancer patients burdened by stress and family conflicts before surgery may face a higher risk for complications following their operation, according to a study published in a recent issue of the Journal of Gastrointestinal Surgery.

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CDC: Almost Everyone Needs a Flu Shot

THURSDAY, Sept. 18, 2014 (HealthDay News) -- Less than half of all Americans got a flu shot last year, so U.S. health officials on Thursday urged that everyone 6 months and older get vaccinated for the coming flu season. "It's really unfortunate that half of Americans are not getting the protection from flu they could get," said Thomas Frieden, M.D., director of the U.S. Centers for Disease Control and Prevention, during a morning news conference.

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Strategies Can Help Docs Lower Their Tax Burden

THURSDAY, Sept. 18, 2014 (HealthDay News) -- Strategies are presented to help physicians lower their tax burden in an article published Sept. 2 in Medical Economics.

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Wild Berry May Boost Effect of Chemo for Pancreatic Cancer

THURSDAY, Sept. 18, 2014 (HealthDay News) -- The use of micronutrients such as chokeberry extract may augment the cytotoxic effects of chemotherapy drugs on cancer cells, according to research published online Sept. 17 in the Journal of Clinical Pathology.

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ASTRO Issues Second List of Choosing Wisely Guidelines

THURSDAY, Sept. 18, 2014 (HealthDay News) -- The American Society for Radiation Oncology (ASTRO) has released a second list of five radiation oncology-specific treatments that should be discussed before being prescribed, as part of the national Choosing Wisely campaign.

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PET-CT Prognostic After Induction Tx in Follicular Lymphoma

THURSDAY, Sept. 18, 2014 (HealthDay News) -- The five-point Deauville scale (5PS), used to score 18F-fluorodeoxyglucose (FDG) uptake on FDG positron emission tomography-computed tomography (PET-CT) scans, has prognostic value in follicular lymphoma, according to a study published online Sept. 18 in The Lancet Haematology.

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Internists Report Considerable EMR-Linked Time Loss

WEDNESDAY, Sept. 17, 2014 (HealthDay News) -- Use of electronic medical record (EMR) systems is associated with considerable loss of free time per clinic day, according to a research letter published online Sept. 8 in JAMA Internal Medicine.

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Doctors Promoting Transparency With Patients

WEDNESDAY, Sept. 17, 2014 (HealthDay News) -- Efforts to increase transparency among doctors are underway, according to an article published in The Boston Globe.

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Most Treatments for Acute VTE Appear Safe, Effective

WEDNESDAY, Sept. 17, 2014 (HealthDay News) -- Almost all the various treatment options for acute venous thromboembolism are equally safe and effective, according to research published in the Sept. 17 issue of the Journal of the American Medical Association.

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Urine Test for Cervical HPV Demonstrates Good Accuracy

WEDNESDAY, Sept. 17, 2014 (HealthDay News) -- A simple urine test can routinely spot human papillomavirus (HPV), according to research published online Sept. 16 in The BMJ.

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Screening Elderly Women for Breast Cancer Questioned

WEDNESDAY, Sept. 17, 2014 (HealthDay News) -- Including women older than 70 in national breast cancer screening programs won't lead to a sharp reduction in advanced forms of the disease, according to researchers who published their study findings online Sept. 15 in The BMJ.

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CDC: Opioid-Related Deaths Quadrupled in Past Decade

TUESDAY, Sept. 16, 2014 (HealthDay News) -- The number of Americans dying from accidental overdoses of opioid analgesics jumped significantly from 1999 to 2011, according to a September data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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AACR: Targeted Drugs Among Successes Against Cancer

TUESDAY, Sept. 16, 2014 (HealthDay News) -- About 14.5 million U.S. cancer survivors are alive today, compared to just three million in 1971, the American Association for Cancer Research reported Tuesday.

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FDA Approves Movantik for Opioid-Induced Constipation

TUESDAY, Sept. 16, 2014 (HealthDay News) -- Movantik (naloxegol) has been approved by the U.S. Food and Drug Administration to treat opioid-induced constipation, the agency said Tuesday.

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Over a Quarter of Hospital Orders Classified As Defensive

TUESDAY, Sept. 16, 2014 (HealthDay News) -- More than one-quarter of hospital medicine services were rated by ordering physicians as at least a partially defensive order, according to a research letter published online Sept. 15 in JAMA Internal Medicine.

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Male Pattern Baldness Tied to Prostate Cancer

MONDAY, Sept. 15, 2014 (HealthDay News) -- Men with male pattern baldness may face a higher risk of developing an aggressive type of prostate cancer than men with no balding, according to a study published online Sept. 15 in the Journal of Clinical Oncology.

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HPV Vaccine Knowledge Doesn't Predict Vaccination

MONDAY, Sept. 15, 2014 (HealthDay News) -- Neither parents' nor adolescents' knowledge about human papillomavirus (HPV) vaccines predicts vaccination compliance, according to a study published online Sept. 15 in Pediatrics.

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Watchful Waiting May Not Be Best for Black Men With Prostate CA

MONDAY, Sept. 15, 2014 (HealthDay News) -- Watchful waiting may not be suitable for all men with early-stage prostate cancer, especially black patients, according to research published in Urologic Oncology.

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New Role of Patient As Consumer Requires Market Changes

FRIDAY, Sept. 12, 2014 (HealthDay News) -- The new consumer retail market in U.S. health care is necessary and will benefit consumers, and as consumers take on more costs of care, access to information to help them make informed decisions is crucial, according to a recent white paper published by Vitals.

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Errata Frequently Seen in Medical Literature

MONDAY, Sept. 15, 2014 (HealthDay News) -- Errata, including those that may materially change the interpretation of data, are frequent in medical publications, according to a study published in the August issue of The American Journal of Medicine.

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Non-Vitamin K Oral Anticoagulants Vary in Assay Effects

FRIDAY, Sept. 12, 2014 (HealthDay News) -- Non-vitamin K oral anticoagulants exhibit variable effects on coagulation assays, according to a study published in the Sept. 16 issue of the Journal of the American College of Cardiology.

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Researchers Support Lung Cancer CT Screen in Older Patients

FRIDAY, Sept. 12, 2014 (HealthDay News) -- Individuals aged 65 to 74 years with a history of smoking should not be excluded from screening with low-dose computed tomography (LDCT) for lung cancer, according to researchers who published their study findings online Sept. 9 in the Annals of Internal Medicine.

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Factors ID'd for CRC Risk Stratification With Positive FIT

THURSDAY, Sept. 11, 2014 (HealthDay News) -- Fecal hemoglobin concentration, sex, and age can be used to classify the risk of advanced colorectal neoplasia among individuals with positive results from fecal immunochemical tests (FITs), according to a study published in the September issue of Gastroenterology.

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Half of Staff Believe Dignified Death Possible in Cancer Centers

THURSDAY, Sept. 11, 2014 (HealthDay News) -- About half of cancer center staff members perceive that a dignified death is possible for cancer patients on their wards, according to a study published online Sept. 8 in Cancer.

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Physician Describes Impact of Malpractice Suit

THURSDAY, Sept. 11, 2014 (HealthDay News) -- A family doctor who was involved in a malpractice suit describes the impact on her practice of medicine in an article published online in the September/October issue of the Annals of Family Medicine.

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Fear About Disease Progression Prompts ER Returns

THURSDAY, Sept. 11, 2014 (HealthDay News) -- Perceived inability to access timely follow-up care and uncertainty and fear about disease progression are the main reasons for return visits to the emergency department, according to a study published online Sept. 2 in the Annals of Emergency Medicine.

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AB Blood Type May Be Linked to Risk of Memory Loss

THURSDAY, Sept. 11, 2014 (HealthDay News) -- Blood group AB and higher factor VIII are associated with increased incidence of cognitive impairment, according to a study published online Sept. 10 in Neurology.

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Single Random Biopsy Ups Detection of Cervical Disease

WEDNESDAY, Sept. 10, 2014 (HealthDay News) -- In women with negative colposcopy, a single random biopsy increases detection of high-grade cervical disease, according to a study published online Sept. 8 in Obstetrics & Gynecology.

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Recommendations Developed for Sickle Cell Disease

WEDNESDAY, Sept. 10, 2014 (HealthDay News) -- Evidence-based recommendations have been developed to support health care professionals who provide care for individuals with sickle cell disease. The summary of the 2014 evidence-based report by expert panel members was published online Sept. 9 in the Journal of the American Medical Association.

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Reanalyses of RCTs Can Lead to Different Conclusions

WEDNESDAY, Sept. 10, 2014 (HealthDay News) -- More than one-third of the small number of reanalyses of randomized clinical trials (RCTs) have implied conclusions different from those of the original articles, according to a study published online Sept. 9 in the Journal of the American Medical Association.

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Meta-Analysis: Prediabetes Linked to Increased Cancer Risk

WEDNESDAY, Sept. 10, 2014 (HealthDay News) -- Prediabetes is associated with an elevated risk of cancer overall and with increased risks of site-specific cancers, including liver, endometrial, and stomach/colorectal cancer, according to a meta-analysis published online Sept. 8 in Diabetologia.

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For Some, Health Insurance More Costly Than Uninsured Penalty

TUESDAY, Sept. 9, 2014 (HealthDay News) -- For some young people in the United States, the cost of paying a penalty for not buying health insurance will be lower than the lowest-cost insurance, according to a study published online Sept. 9 in the Annals of Internal Medicine.

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ASCO/CCO Issue New Guidelines for Advanced Prostate Cancer

TUESDAY, Sept. 9, 2014 (HealthDay News) -- Guidelines, issued jointly by the American Society of Clinical Oncology (ASCO) and Cancer Care Ontario (CCO) in Canada, highlight recent advances in treating hormone-therapy-resistant advanced prostate cancer. The guidelines were published Sept. 8 in the Journal of Clinical Oncology.

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Renal and Thyroid Cancers on the Rise in U.S. Children

MONDAY, Sept. 8, 2014 (HealthDay News) -- The incidence of renal cancer and thyroid cancer is increasing among children and adolescents in the United States, according to research published online Sept. 8 in Pediatrics.

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Report Explores Patients' Portal Preferences

MONDAY, Sept. 8, 2014 (HealthDay News) -- Patients want portals that include features such as appointment scheduling, viewing test results, and checking prescription refills, and are frustrated with unresponsive staff and poor interfaces, according to a report published by Software Advice.

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Is Soy a Foe to Women With Breast Cancer?

MONDAY, Sept. 8, 2014 (HealthDay News) -- Soy protein may increase activity in genes linked to breast cancer growth -- at least in certain women who already have the disease, according to research reported in the September issue of the Journal of the National Cancer Institute.

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Health Care Spending Expected to Rise in 2014 Through 2023

MONDAY, Sept. 8, 2014 (HealthDay News) -- While health spending growth was slow in 2013, health spending is expected to increase in 2014 and remain higher through 2023, according to a study published online Sept. 3 in Health Affairs.

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Bra Wearing Does Not Up Risk of Breast Cancer

FRIDAY, Sept. 5, 2014 (HealthDay News) -- Wearing a bra does not appear to increase the risk of developing breast cancer, according to research published online Sept. 5 in Cancer Epidemiology, Biomarkers & Prevention.

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FDA: Keytruda Approved for Advanced Melanoma

FRIDAY, Sept. 5, 2014 (HealthDay News) -- Keytruda (pembrolizumab) has been approved by the U.S. Food and Drug Administration to treat patients with advanced melanoma who are no longer responding to other drugs.

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Blog: Seven Most Common Physician Social Media Misses

THURSDAY, Sept. 4, 2014 (HealthDay News) -- The most common physician social media misses and missteps can be avoided, allowing doctors to take advantage of marketing opportunities on all major social media channels, according to the author of a recent Vitals blog.

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Guidelines Issued for HER2-Negative Advanced Breast Cancer

THURSDAY, Sept. 4, 2014 (HealthDay News) -- Evidence-based recommendations have been developed for chemotherapy and targeted therapy for women with human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. The clinical practice guideline was published online Sept. 2 in the Journal of Clinical Oncology.

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New Myeloma Treatment Options Show Promise

THURSDAY, Sept. 4, 2014 (HealthDay News) -- New multiple myeloma treatment options appear promising for patients aged 65 years and younger and for newly diagnosed patients who are ineligible for stem-cell transplantation, according to two studies published in the Sept. 4 issue of the New England Journal of Medicine.

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Increased Melanoma Incidence for Pilots, Cabin Crew

THURSDAY, Sept. 4, 2014 (HealthDay News) -- Airline pilots and cabin crew have an increased incidence of melanoma, according to a meta-analysis published online Sept. 3 in JAMA Dermatology.

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ASCO: Family Docs Can Up Return Rates for Mammograms

THURSDAY, Sept. 4, 2014 (HealthDay News) -- A personalized letter from a family physician may help improve return rates for screening mammography, according to research scheduled to be presented at the American Society of Clinical Oncology's 2014 Breast Cancer Symposium, held from Sept. 4 to 6 in San Francisco.

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AR-V7 Linked to Chemotherapy Resistance in Prostate Cancer

WEDNESDAY, Sept. 3, 2014 (HealthDay News) -- For patients with castration-resistant prostate cancer, detection of androgen-receptor splice variant 7 messenger RNA (AR-V7) in circulating tumor cells appears to be associated with enzalutamide and abiraterone resistance, according to a study published online Sept. 3 in the New England Journal of Medicine.

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Venous Thromboembolism Rare After Urological Procedures

WEDNESDAY, Sept. 3, 2014 (HealthDay News) -- Deep venous thrombosis (DVT) and pulmonary embolism (PE) are uncommon after urological surgery, according to a study published in the September issue of The Journal of Urology.

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Rate of Bilateral Mastectomy Increased From 1998 to 2011

TUESDAY, Sept. 2, 2014 (HealthDay News) -- For women diagnosed with stage 0 to III breast cancer, the rate of bilateral mastectomy increased from 1998 to 2011, according to a study published in the Sept. 3 issue of the Journal of the American Medical Association.

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