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AACR: Human Papillomavirus Tied to Lung Cancer

High-risk HPV antibodies increased in lung cancer cases compared to controls

MONDAY, April 4 (HealthDay News) -- Several high-risk forms of human papillomavirus (HPV) antibodies may be associated with an increased risk of lung cancer, according to research presented at the annual meeting of the American Association for Cancer Research, held April 2 to 6 in Orlando, Fla.

Devasena Anantharaman, Ph.D., of the International Agency for Research on Cancer in Lyon, France, and colleagues determined the presence of several high-risk and low-risk types of HPV using serological tests in 1,633 individuals with lung cancer and 2,729 matched controls from six central European countries.

The investigators found that antibodies to proteins in eight types of high-risk HPV were significantly increased among individuals with lung cancer. However, a low prevalence of antibodies to all types of HPV tested was found among controls. The investigators also found that smoking did not account for this effect, as the results were consistent in current smokers, former smokers, and those who never smoked.

"While a number of previous studies have demonstrated the presence of HPV in lung cancer, their statistical power has been limited by small average sample size and variations in methodology," Anantharaman said in a statement. "We know that HPV can reach the lung, but whether HPV can cause frank malignancies is a question we hope to answer."

Abstract No. 1890
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