Method Images Oxygenation and Metabolites in Tumors

Combines functional and anatomic imaging

MONDAY, April 28 (HealthDay News) -- A real-time method combining functional and anatomic imaging can produce a map of oxygenation and metabolite levels in tumors, according to study findings published online April 22 in the Journal of Clinical Investigation.

Shingo Matsumoto, and colleagues from the National Institutes of Health in Bethesda, Md., evaluated a combined system of pulsed electron paramagnetic resonance imaging to measure the real-time partial pressure of oxygen and MRI to provide anatomic guidance to evaluate oxygenation in mice with a squamous cell carcinoma.

The researchers found that even regions of the tumor with blood flow had significant hypoxia. Areas that had normal oxygenation also had significant levels of lactate, suggesting predominantly aerobic glycolysis.

"This technique, combining functional and anatomic imaging, shows immediate preclinical applicability in monitoring factors that control tumor hypoxia and metabolism and may have future clinical potential for monitoring tumor response to treatment," Ashley A. Manzoor, and colleagues from Duke University in Durham, N.C., write in an accompanying editorial.

Full Text

Physician's Briefing