See What HealthDay Can Do For You
Contact Us

Pre-Op MRI of Margins Predicts Rectal Cancer Outcomes

Circumferential resection margin predicts overall survival, disease-free survival, local recurrence

Pre-Op MRI of Margins Predicts Rectal Cancer Outcomes

FRIDAY, Dec. 6, 2013 (HealthDay News) -- Preoperative high-resolution magnetic resonance imaging (MRI) assessment of circumferential resection margin (CRM) status predicts survival and other disease progression outcomes in patients with rectal cancer, according to a study published online Nov. 25 in the Journal of Clinical Oncology.

Fiona G.M. Taylor, from Mayday University Hospital in Croydon, U.K., and colleagues conducted a follow-up study in 374 patients with rectal cancer. Preoperative high-resolution pelvic MRIs were used to assess CRM, and the relationship of MRI assessment and outcomes were evaluated.

The researchers found that five-year overall survival (OS) was 62.2 percent in patients with MRI-clear CRM compared to 42.2 percent in patients with MRI-involved CRM (hazard ratio, 1.97). Disease-free survival (DFS) at five years was 67.2 percent for MRI-clear CRM versus 47.3 percent for MRI-involved CRM (hazard ratio, 1.65). For MRI-involved CRM, local recurrence (LR) was 3.50. In multivariate analysis, MRI-involved CRM was the only preoperative staging parameter that remained significant for OS, DFS, and LR.

"High-resolution MRI preoperative assessment of CRM status is superior to American Joint Committee on Cancer TNM-based criteria for assessing risk of LR, DFS, and OS," the authors write.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.