See What HealthDay Can Do For You
Contact Us

In Prostate Cancer, BMI at Diagnosis Linked to Mortality

Odds of mortality up with increasing BMI; strongest effect for men with Gleason score 8+

In Prostate Cancer, BMI at Diagnosis Linked to Mortality

FRIDAY, Nov. 1 (HealthDay News) -- For men with prostate cancer, body mass index (BMI) at diagnosis is associated with mortality, according to a study published online Aug. 6 in Obesity Research & Clinical Practice.

Reina Haque, Ph.D., M.P.H., from Kaiser Permanente Southern California in Pasadena, and colleagues conducted a population-based case-control study involving 751 men with prostate cancer who underwent radical prostatectomy to examine the correlation between BMI at diagnosis and prostate cancer mortality. The cohort included 323 cases who died from prostate cancer and 428 matched controls.

The researchers found that more cases than controls were obese (≥30 kg/m²: 30 versus 22 percent). Compared with men with healthy BMI, obese men had a significant increase in prostate cancer mortality (adjusted odds ratio, 1.50). The odds of mortality generally increased with increasing BMI, after stratification by Gleason score. The strongest effect was seen for men in the Gleason score 8+ category (odds ratio, 2.37). The correlations persisted even after adjustment for tumor characteristics and prostate-specific antigen at diagnosis.

"In conclusion, results for this study suggest that obese men are more likely to die from prostate cancer when compared to non-obese men and this association is strongest among men with higher Gleason scores," the authors write.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.