See What HealthDay Can Do For You
Contact Us

Multi-Parametric MRI Shows Benefit As Triage Test

Research shows MP-MRI could reduce unnecessary prostate biopsies

prostate cancer

MONDAY, Jan. 23, 2017 (HealthDay News) -- For men with high serum prostate-specific antigen, multi-parametric magnetic resonance imaging (MP-MRI) is more sensitive but less specific than transrectal ultrasound guided prostate biopsy (TRUS-biopsy) for detecting clinically significant cancer, and can be used as a triage test to avoid unnecessary biopsy, according to a study published online Jan. 19 in The Lancet.

Hashim U. Ahmed, M.D., Ph.D., from University College London, and colleagues examined the diagnostic accuracy of MP-MRI and TRUS-biopsy against a reference test (template prostate mapping biopsy [TPM-biopsy]) in a multicenter, paired-cohort study. Five hundred seventy-six men with prostate-specific antigen concentrations up to 15 ng/mL without previous biopsy were recruited and underwent 1.5 Tesla MP-MRI, TRUS-biopsy, and TPM-biopsy.

The researchers found that 71 percent of men had cancer on TPM-biopsy, with 40 percent of patients clinically significant. For clinically significant cancer, MP-MRI was more sensitive (93 versus 48 percent; P < 0.0001) and less specific (41 versus 96 percent; P < 0.0001) than TRUS-biopsy. Overall, 5.9 percent of patients reported serious adverse events, including eight sepsis cases.

"MP-MRI, used as a triage test before first prostate biopsy, could reduce unnecessary biopsies by a quarter," the authors write. "MP-MRI can also reduce over-diagnosis of clinically insignificant prostate cancer and improve detection of clinically significant cancer."

Several authors disclosed financial ties to the biopharmaceutical and medical device industries.

Full Text

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.